Abstract:
The low incidence of vincristine-induced peripheral neuropathy (VIPN) in Kenyan
children may result from low vincristine exposure. We studied vincristine expo-
sure in Kenyan children and dose-escalated in case of low vincristine exposure
(NCT05844670). Average vincristine exposure was high. Individual vincristine expo-
sure was assessed with a previously developed nomogram. A 20% dose increase was
recommended for participants with low exposure and no VIPN, hyperbilirubinemia, or
malnutrition. None of the 15 participants developed VIPN. Low vincristine exposure
was seen in one participant: a dose increase was implemented without side effects.
In conclusion, the participants did not develop VIPN despite having high vincristine
exposure.
