dc.contributor.author | Liu, Zhiwei | |
dc.contributor.author | Luo, Yang | |
dc.contributor.author | Kirimunda, Samuel | |
dc.contributor.author | Verboom, Murielle | |
dc.contributor.author | Onabajo, lusegun O. | |
dc.contributor.author | Gouveia, Mateus H. | |
dc.contributor.author | Ogwang, Martin D. | |
dc.contributor.author | Kerchan, Patrick | |
dc.contributor.author | Reynolds, Steven J. | |
dc.contributor.author | Tenge, Constance N | |
dc.contributor.author | Were, Pamela A. | |
dc.contributor.author | Kuremu, Robert T. | |
dc.contributor.author | Wekesa, Walter N. | |
dc.contributor.author | Masalu, Nestory | |
dc.contributor.author | Kawira, Esther | |
dc.contributor.author | Kinyera, Tobias | |
dc.contributor.author | Otim, Isaac | |
dc.contributor.author | Legason, Ismail D | |
dc.contributor.author | Nabalende, Hadijah | |
dc.contributor.author | Dhudha, Herry | |
dc.contributor.author | Ayers, Leona W. | |
dc.contributor.author | Bhatia, Kishor | |
dc.contributor.author | Goedert, James J. | |
dc.contributor.author | Cole, Nathan | |
dc.contributor.author | Luo, Wen | |
dc.contributor.author | Liu, Jia | |
dc.contributor.author | Manning, Michelle | |
dc.contributor.author | Hicks, Belynda | |
dc.contributor.author | Prokunina-Olsson, Ludmila | |
dc.contributor.author | Chagaluka, George | |
dc.contributor.author | Johnston, W. Thomas J | |
dc.contributor.author | Mutalima, Nora | |
dc.contributor.author | Borgstein, Eric | |
dc.contributor.author | Liomba, George N. | |
dc.contributor.author | Kamiza, Steve | |
dc.contributor.author | Mkandawire, Nyengo | |
dc.contributor.author | Mitambo, Collins | |
dc.contributor.author | Molyneux, Elizabeth M | |
dc.contributor.author | Newton, , Robert | |
dc.contributor.author | Hsing, Ann W. | |
dc.contributor.author | . Mensah, James E | |
dc.contributor.author | Adjei, Anthony A. | |
dc.contributor.author | Hutchinson, Amy | |
dc.contributor.author | Carrington, Mary | |
dc.contributor.author | Yeage, Meredith | |
dc.contributor.author | Blasczyk, Rainer | |
dc.contributor.author | . Chanock, Stephen J | |
dc.contributor.author | Raychaudhuri, Soumya | |
dc.contributor.author | Mbulaiteye, Sam M. | |
dc.date.accessioned | 2024-05-16T12:50:37Z | |
dc.date.available | 2024-05-16T12:50:37Z | |
dc.date.issued | 2024-01-05 | |
dc.identifier.uri | https://doi.org/10.1038/s42003-023-05701-5 | |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/9103 | |
dc.description.abstract | Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymorphisms, which reg- ulate immune response, are associated with BL has not been well investigated, which limits our understanding of BL etiology. Here we investigate this association among 4,645 children aged 0-15 years, 800 with BL, enrolled in Uganda, Tanzania, Kenya, and Malawi. HLA alleles are imputed with accuracy >90% for HLA class I and 85-89% for class II alleles. BL risk is elevated with HLA-DQA1*04:01 (adjusted odds ratio [OR] = 1.61, 95% confidence interval [CI] = 1.32-1.97, P = 3.71 × 10−6), with rs2040406(G) in HLA-DQA1 region (OR = 1.43, 95% CI = 1.26-1.63, P = 4.62 × 10−8), and with amino acid Gln at position 53 versus other variants in HLA-DQA1 (OR = 1.36, P = 2.06 × 10−6 ). The associations with HLA-DQA1*04:01 (OR = 1.29, P = 0.03) and rs2040406(G) (OR = 1.68, P = 0.019) persist in mutually adjusted models. The higher risk rs2040406(G) variant for BL is associated with decreased HLA-DQB1 expression in eQTLs in EBV transformed lymphocytes. Our results support the role of HLA variation in the etiology of BL and suggest that a promising area of research might be understanding the link between HLA variation and EBV control. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Burkitt lymphoma | en_US |
dc.subject | Childhood cancers | en_US |
dc.subject | Chronic infection | en_US |
dc.title | Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma | en_US |
dc.type | Article | en_US |
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |