dc.description.abstract |
The purpose of this study was to design and test the effectiveness of two pH-
dependent coatings in delivering intact barium sulfate caplets to the large intestine. In the
future, this work will enable us to non-invasively assess the absorption of folate across
the human colon. Barium sulphate caplet cores were coated with Eudragit L100 and
S100, in either a 1:0 or 3:1 ratio. Each formulation was administered to ten volunteers,
and monitored in-vivo via fluoroscopy. Test caplets with 3:1 coating formulations had
40% higher colon-targeting specificity compared to 1:0 caplets, and tended to begin
dissolving at a later time after administration (p=0.09). The total time from
administration to complete dissolution was also significantly longer for 3:1 coated caplets
(p=0.003). These results suggest that barium sulphate caplets with a 3:1 (Eudragit
L100:S100) coating formulation ratio would be a suitable delivery system for
investigating the absorption of folate across the large intestine. |
en_US |