Abstract:
Background: Pulmonary tuberculosis (PTB) is the commonest clinical presentation of
tuberculosis. It has been declared a global public health emergency by WHO. It’s the
commonest opportunistic infection and cause of death in people infected with HIV. Chest
radiography is useful in diagnosis and assessing response to therapy. Chest radiograph features
in people with PTB and HIV co infection are atypical and are affected by CD4 levels. Some
recent literature suggests that some of the features are changing in different geographic
locations.
Objective: To determine chest radiograph features in relation to CD4 counts in adult patients
with smear positive PTB and HIV co infection at MTRH
Study design: A cross sectional study
Setting: Chest clinic at MTRH, Kenya
Subjects: Newly diagnosed smear positive, HIV positive patients aged 16 years and above
Methods: 115 patients (using Fischer’s formula with finite population adjustment) were studied
between October 2011 and November 2012. Data on demographics, clinical presentation,
physical examination findings, CD4 counts and chest radiograph findings were collected and
analysed using STATA version 12. Descriptive statistics were carried out for continuous
variables using mean, median, standard deviation and inter-quartile range. Frequency tables
were generated for categorical variables. The chi square test and Fishers’ exact test were used to
test for any associations. A p-value < 0.05 was considered statistically significant.
Results: 55% of those studied were male. The mean age was 36 years. 58% of the patients had
CD4 counts below 200cells/mm 3 , 61% of whom were male. The most common radiograph
patterns, in order of frequency, were pulmonary infiltrates (60%), cavitations (25.2%), normal
(23.5%), interstitial pattern (19.1%), consolidation (13.9%), pleural effusion (13%), scarring
(9.6%), miliary pattern (9.6%) and hilar lymphadenopathy (1.7%). Normal radiographs and
miliary pattern showed a significant association with CD4 counts below 200cell/mm 3 (p=0.001
and 0.014 respectively). Consolidation, scarring and pleural effusion had a significant
association with CD4 counts above 350cells/mm 3 (p=0.001, 0.024 and 0.006 respectively). The
other radiograph patterns showed no significant association with CD4 level.
Conclusion: Pulmonary infiltrates is the most common radiographic pattern in patients with
smear positive PTB/HIV co infection. Normal radiographs and miliary pattern are significantly
associated with CD4 counts below 200cells/mm 3 , while consolidation, scarring and pleural
effusion have a significant association with CD4 counts above 350cells/mm 3 .