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Distinct viral and mutational spectrum of Endemic Burkitt Lymphoma

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dc.contributor.author Ndede, Isaac
dc.contributor.author Kirtika, Patel
dc.date.accessioned 2022-01-25T06:39:14Z
dc.date.available 2022-01-25T06:39:14Z
dc.date.issued 2015-10
dc.identifier.uri http://ir.mu.ac.ke:8080/jspui/handle/123456789/5779
dc.description.abstract Endemic Burkitt lymphoma (eBL) is primarily found in children in equatorial regions and rep- resents the first historical example of a virus-associated human malignancy. Although Epstein-Barr virus (EBV) infection and MYC translocations are hallmarks of the disease, it is unclear whether other factors may contribute to its development. We performed RNA-Seq on 20 eBL cases from Uganda and showed that the mutational and viral landscape of eBL is more complex than previously reported. First, we found the presence of other her- pesviridae family members in 8 cases (40%), in particular human herpesvirus 5 and human herpesvirus 8 and confirmed their presence by immunohistochemistry in the adjacent non- neoplastic tissue. Second, we identified a distinct latency program in EBV involving lytic genes in association with TCF3 activity. Third, by comparing the eBL mutational landscape with published data on sporadic Burkitt lymphoma (sBL), we detected lower frequencies of mutations in MYC, ID3, TCF3 and TP53, and a higher frequency of mutation in ARID1A in eBL samples. Recurrent mutations in two genes not previously associated with eBL were identified in 20% of tumors: RHOA and cyclin F (CCNF). We also observed that polyviral samples showed lower numbers of somatic mutations in common altered genes in compari- son to sBL specimens, suggesting dual mechanisms of transformation, mutation versus virus driven in sBL and eBL respectively. en_US
dc.language.iso en en_US
dc.publisher PLOS Pathogens en_US
dc.subject Mutational spectrum en_US
dc.subject Endemic burkitt lymphoma en_US
dc.title Distinct viral and mutational spectrum of Endemic Burkitt Lymphoma en_US
dc.type Article en_US


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