dc.description.abstract |
Background: Liver cirrhosis is a chronic, progressive liver disease characterized by scarring
of the liver and nodule formation. The most common causes are hepatitis and chronic
alcoholism. It is ranked as the 14th most common cause of death worldwide. The clinical
diagnosis of cirrhosis is based on a combination of clinical, biological and radiological
findings. Hepatobiliary Doppler ultrasound is a valuable noninvasive and widely available
tool in evaluating the hemodynamics and caliber of portal venous system and hepatic vessels.
It helps in assessment of the severity of liver cirrhosis and complications such as portal
hypertension allowing prompt intervention and prevention of further complications. Portal
vein Congestive Index (CI) is a marker of increased portal pressures. However, there is
underutilization and paucity of data on the role of Doppler ultrasound in our setup.
Objectives: To describe the Doppler ultrasound findings of portal and hepatic vessels and
ultrasound features associated with portal hypertension in patients with clinically diagnosed
liver cirrhosis.
Methods: This was a cross-sectional study conducted among adult patients with clinical
diagnosis of liver cirrhosis from May 2019 to April 2020. A census sampling was used to
recruit eligible participants.65 participants were studied. A data collection tool was used to
record age, gender, history of alcohol consumption, jaundice, hepatitis infection titers,
hepatobiliary gray scale and Doppler ultrasound findings. Mindray M7, a portable ultrasound
machine with exquisite Doppler capability was used, utilizing 3.5-5 MHz curvilinear
transducer (Doppler angle <60º).Continuous variables were analyzed using mean, median,
and their corresponding standard deviation and interquartile ranges while categorical
variables were summarized as proportions and percentages. Chi square test and Fischer's
exact test were done to assess association between liver span, echogenicity and hepatofugal
flow. Mann Whitney U test was done to assess the differences in the distribution of
continuous variables (portal vein velocity, diameter, CI and Hepatic Artery Resistive Index)
among the categorical variables (ascites, splenomegaly and hepatofugal flow). A P value of
less than 0.05 was considered significant.
Results: 41/65(63.1%) were male. The mean age was 47 years (SD=7.8).42/65(64.6%) had
liver surface irregularities and 25/65(38.5%) had hyperechoic parenchymal echogenicity.
35/65 (53.8%) had ascites while 32/65 (49.2%) had splenomegaly. 18/65 (27.7%) had
hepatofugal flow. 22/65 (33.8%) had non-triphasic hepatic vein waveform. The mean portal
vein velocity, portal vein diameter, CI and Hepatic Artery Resistive Index (HARI) were 13.49
cm/s, 12.73mm, 0.13 and 0.76 respectively. Increasing HARI and CI were significantly
associated with hepatofugal flow (p<0.001,<0.001), ascites (p=0.025,0.001) and
splenomegaly (p=0.023,<0.001).
Conclusion: Majority of the patients had liver surface irregularities with about half of the
patients having increased main portal vein diameter. Increasing HARI and Congestive Index
were significantly associated with presence of ascites, splenomegaly and hepatofugal flow.
Recommendation: There is need for routine ultrasonography evaluation with emphasis on
Doppler studies of the hemodynamic changes in patients with liver cirrhosis. Prospective
studies be done to further determine the strengths of association. |
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