Abstract:
Background: Acute ischemic stroke is a major cause of death worldwide. About 80%
of strokes are thromboembolic in origin, with carotid plaque as an embolic source.
Carotid Doppler ultrasound is valuable to assess the localization, extent, and severity
of extracranial carotid stenosis. It is a safe, accurate, and affordable alternative to
Computed Tomography Angiography. However, limited studies have been done in
our population.
Objectives: To describe the patterns of carotid Doppler ultrasound, the proportion of
Internal Carotid Artery(ICA) stenosis, and its associated factors among ischemic
stroke patients at Moi Teaching and Referral Hospital.
Methods: This was a cross-sectional study conducted among patients who presented
with a CT diagnosis of acute ischemic stroke from September 2018 to August 2019. A
census methodology was used and a total of 71 participants were recruited.
A data collection form was utilized to record age, gender, history of known risk
factors such as diabetes, hypertension, and smoking and findings of carotid Doppler
ultrasound. The 7.5 MHz linear array transducer of the Mindray M7 machine was
used (Doppler angle <60º). The Mindray M7 is an ultrasound machine with superior
image quality and exquisite Doppler capability. Stratification of ICA stenosis was
done based on the United States Society of radiologists in ultrasound consensus
criteria of 2004. Continuous variables were summarized using means and standard
deviations. Categorical variables were summarized in frequency, percentages and bar
graphs. Chi-square test and Fischer’s exact test were done to assess the relationship
between stenosis and associated factors. Mann Whitney U test was used to determine
association between distribution of age and stenosis. P value of less than 0.05 was
considered significant
Results: Of the participants studied, 42/71(59.2%)were male. The mean age was 64.2
years (SD=11.0). Increased Intima Media Thickness (>1 mm) was seen in
43/142(30.3%) of the common carotid arteries. 41 plaques were identified. The
commonest site of plaque was the ICA 21/41(51.3%) followed by the carotid bulb
9/41 (21.9%) and the CCA 9/41 (21. 9%), where 28/41(68.3%) were characterized as
homogenous, 7/41(17.1%) heterogeneous and 6/41(14.6%) were calcified. Mild ICA
stenosis was seen in 20/71(28.2%) patients followed by 5/71(7%) with moderate
stenosis, 2/71(2.8%) had severe stenosis while 1/71(1.4%) had near total occlusion.
There was a statistically significant relation between diabetes, hypertension and
smoking with ICA stenosis, P-values of <0.001, 0.025 and 0.032 respectively.
Individuals with stenosis had a higher age (mean rank= 38.27) compared with those
without stenosis (mean rank = 34.52). However, age and gender did not show any
significant association with stenosis.
Conclusion: ICA was the most common site for plaque formation, with homogenous
plaques being the most common. The proportion of patients with significant stenosis
was low. Having Diabetes, hypertension and a smoking history was associated with
carotid artery stenosis
Recommendation: Routine screening of patients above 50 years with a history of
diabetes, hypertension and smoking is recommended. Prospective studies be done to
further assess the strengths of association.