Abstract:
Background: Ultrasound-guided percutaneous renal biopsy (USG PRB) is a
minimally invasive procedure involving real-time ultrasonographic guidance, a
spring-loaded biopsy gun, and with or without a coaxial needle. However, a wide
range of complications has been reported, such as arteriovenous fistulas, small
perirenal hematomas, large actively bleeding perirenal hematomas, which might
require intervention like blood transfusion, embolization and nephrectomy. In some
cases, death was reported.
Objective: To assess the indications, immediate complications and tissue adequacy of
Ultrasound-guided percutaneous renal biopsy at Moi Teaching and Referral Hospital-
Eldoret Kenya.
Methods: This was a census, a prospective descriptive study conducted among 48
adult patients scheduled for USG PRB from November 2019 to October 2020.
A data collection form was utilized to record age, gender, pre-biopsy laboratory
findings, renal biopsy indications, post-biopsy complication findings and tissue
adequacy. Biopsies were taken by the consultant radiologist under ultrasound
guidance using a 3.5-5MHZ curvilinear transducer of Mindray M7 (ultrasound
machine with exquisite Doppler and greyscale capability), coaxial needle and biopsy
gun. A two to five core tissues were obtained. Biopsy tissues were considered
adequate if they contained at least eight glomeruli for native kidneys. One core tissue
length more than 10mm for renal masses and a histopathologist can make a diagnosis.
Continuous variables were summarized using means and standard deviations.
Categorical variables were summarized in frequency, percentages and bar graphs.
Fisher's exact test was done to assess the relationship between complications and
associated factors. A p-value of less than 0.05 considered significant.
Results: The mean age was 34.8 years (SD=13.1). The majority of the participants
(52.1%) were females. Nephrotic syndrome was the commonest indication for renal
biopsy (45.8%) followed by renal masses (25.0%), SLE (20.8%) and nephritic
syndrome (8.3%). The overall complications were 8(16.7%). Seven patients (14.6%)
developed minor complications, namely, macrohematuria (n=5) and perirenal
hematoma less than 5cm (n=2). One participant (2%) developed a major complication
(perirenal hematoma >5 cm and hypotension) where transfusion and gelfoam
embolization was done. The number of biopsy passes had a statistically significant
association with the complications (p-value < 0.001). However, gender, creatinine and
indications for PRB were not associated with complications. The majority of the
participants (95.8%) whose tissue specimens were obtained were declared adequate
by the histopathologist.
Conclusions: Nephrotic syndrome was the most common indication for Ultrasoundguided
PRB. Macrohematuria was the commonest complication of USG PRB. More
than four biopsy passes were significantly associated with post PRB complications.
Up to 95% of the biopsy tissues were adequate.
Recommendations: Close monitoring for patients done more than 4 biopsy passes is
recommended After USG PRB.