| dc.contributor.author |
Loiseau, Chloé |
|
| dc.contributor.author |
Brites, Daniela |
|
| dc.contributor.author |
Reinhard, Miriam |
|
| dc.contributor.author |
Zürcher, Kathrin |
|
| dc.contributor.author |
Borrell, Sonia |
|
| dc.contributor.author |
Ballif, Marie |
|
| dc.contributor.author |
Fenner, Lukas |
|
| dc.contributor.author |
Cox, Helen |
|
| dc.contributor.author |
Rutaihwa, Liliana K. |
|
| dc.contributor.author |
Wilkinson, Robert J. |
|
| dc.contributor.author |
Yotebieng, Marcel |
|
| dc.contributor.author |
Carter, E. Jane |
|
| dc.contributor.author |
Alash’le, Abimiku |
|
| dc.contributor.author |
Olivier, Marcy |
|
| dc.date.accessioned |
2020-10-14T07:07:38Z |
|
| dc.date.available |
2020-10-14T07:07:38Z |
|
| dc.date.issued |
2020 |
|
| dc.identifier.uri |
https://aac.asm.org/content/64/10/e00782-20 |
|
| dc.identifier.uri |
http://ir.mu.ac.ke:8080/jspui/handle/123456789/3543 |
|
| dc.description.abstract |
We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
American Society |
en_US |
| dc.subject |
HIV-TB coinfection |
en_US |
| dc.subject |
Mycobacterium tuberculosis |
en_US |
| dc.subject |
Drug resistance |
en_US |
| dc.subject |
Fitness cost |
en_US |
| dc.subject |
rifampicin |
en_US |
| dc.title |
HIV coinfection is associated with low-fitness rpoB variants in Rifampicin-resistant mycobacterium tuberculosis |
en_US |
| dc.type |
Article |
en_US |