| dc.contributor.author | Campbell, Mary S. | |
| dc.contributor.author | Kahle, Erin M. | |
| dc.contributor.author | Celum, Connie | |
| dc.contributor.author | Lingappa, Jairam R. | |
| dc.contributor.author | Kapiga, Saidi | |
| dc.contributor.author | Mujugira, Andrew | |
| dc.contributor.author | Mugo, Nelly R. | |
| dc.contributor.author | Fife, Kenneth H. | |
| dc.contributor.author | Mullins, James I. | |
| dc.contributor.author | Baeten, Jared M. | |
| dc.date.accessioned | 2020-07-27T09:03:01Z | |
| dc.date.available | 2020-07-27T09:03:01Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | https://doi.org/10.1093/infdis/jit015 | |
| dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/3122 | |
| dc.description.abstract | Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C–infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Oxford University Press | en_US |
| dc.subject | HIV-1 | en_US |
| dc.subject | Group M subtype | en_US |
| dc.subject | Early infection | en_US |
| dc.subject | Plasma viral load | en_US |
| dc.title | Plasma viral loads during early HIV-1 infection are similar in subtype C– and non-subtype C–infected African seroconverters | en_US |
| dc.type | Article | en_US |
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