dc.contributor.author |
Lingappa, Jairam R. |
|
dc.contributor.author |
Lambdin, Barrot. |
|
dc.contributor.author |
Ann Bukusi, Elizabeth. |
|
dc.contributor.author |
Ngure, Kenneth. |
|
dc.contributor.author |
Kavuma, Linda. |
|
dc.contributor.author |
Inambao, Mubiana. |
|
dc.contributor.author |
Kanweka, William. |
|
dc.contributor.author |
Allen., Susan. |
|
dc.contributor.author |
N. Kiarie, James. |
|
dc.contributor.author |
Makhema, Joseph. |
|
dc.contributor.author |
Were, Edwin. |
|
dc.contributor.author |
Manongi, Rachel. |
|
dc.contributor.author |
Coetzee, David. |
|
dc.contributor.author |
de Bruyn, Guy. |
|
dc.contributor.author |
Delany-Moretlwe, Sinead. |
|
dc.contributor.author |
Magaret, Amalia. |
|
dc.contributor.author |
Mugo, Nelly. |
|
dc.contributor.author |
Mujugira, Andrew. |
|
dc.contributor.author |
Ndase, Patrick. |
|
dc.contributor.author |
Celum, Connie. |
|
dc.date.accessioned |
2020-06-04T09:17:42Z |
|
dc.date.available |
2020-06-04T09:17:42Z |
|
dc.date.issued |
2008-01-01 |
|
dc.identifier.citation |
Citation: Lingappa JR, Lambdin B, Bukusi EA, Ngure K, Kavuma L, et al (2008) Regional Differences in Prevalence of HIV-1 Discordance in Africa and Enrollment of HIV-1 Discordant Couples into an HIV-1 Prevention Trial. |
en_US |
dc.identifier.uri |
http://ir.mu.ac.ke:8080/jspui/handle/123456789/3057 |
|
dc.description.abstract |
Background. Most HIV-1 transmission in Africa occurs among HIV-1-discordant couples (one partner HIV-1 infected and one
uninfected) who are unaware of their discordant HIV-1 serostatus. Given the high HIV-1 incidence among HIV-1 discordant couples
and to assess efficacy of interventions for reducing HIV-1 transmission, HIV-1 discordant couples represent a critical target
population for HIV-1 prevention interventions and prevention trials. Substantial regional differences exist in HIV-1 prevalence in
Africa, but regional differences in HIV-1 discordance among African couples, has not previously been reported. Methodology/
Principal Findings. The Partners in Prevention HSV-2/HIV-1 Transmission Trial (‘‘Partners HSV-2 Study’’), the first large HIV-1
prevention trial in Africa involving HIV-1 discordant couples, completed enrollment in May 2007. Partners HSV-2 Study recruitment
data from 12 sites from East and Southern Africa were used to assess HIV-1 discordance among couples accessing couples HIV-1
counseling and testing, and to correlate with enrollment of HIV-1 discordant couples. HIV-1 discordance at Partners HSV-2 Study
sites ranged from 8–31% of couples tested from the community. Across all study sites and, among all couples with one HIV-1
infected partner, almost half (49%) of couples were HIV-1 discordant. Site-specific monthly enrollment of HIV-1 discordant couples
into the clinical trial was not directly associated with prevalence of HIV-1 discordance, but was modestly correlated with national
HIV-1 counseling and testing rates and access to palliative care/basic health care (r= 0.74, p = 0.09). Conclusions/Significance.
HIV-1 discordant couples are a critical target for HIV-1 prevention in Africa. In addition to community prevalence of HIV-1
discordance, national infrastructure for HIV-1 testing and healthcare delivery and effective community outreach strategies impact
recruitment of HIV-1 discordant couples into HIV-1 prevention trials. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
medical publication |
en_US |
dc.subject |
HIV-1 transmission |
en_US |
dc.subject |
HIV-1-discordant couples |
en_US |
dc.subject |
HIV-1 prevention interventions and prevention trials |
en_US |
dc.title |
Regional Differences in Prevalence of HIV-1 Discordance in Africa and Enrollment of HIV-1 Discordant Couples into an HIV-1 Prevention Trial |
en_US |
dc.type |
Article |
en_US |