Effects of crude roots extracts of senna didymobotrya on caecal amoebiasis in mice

Abstract

A nti - amoebic effects of crude root extracts of Senna didymobotrya against Entamoeba histolytica infecting caecum of mice were studied. Caecal amoebiasis was induced by injection of Entamoeba histolytica trophozoit es directly into the caecum. Mice were treated orally with the root dichlorom ethane extracts , ethyl acetate extracts , methanol total extracts , methanol successive extracts , hexane extracts , water extracts , metronidazole and normal s aline for five consecutive days a nd examined on the sixth day. At a dose of 500 mg/ g / day, root extracts of dichloromethane, ethyl acetate, methanol total, methanol successive, hexane and water had a curative rate of 50, 66.7,100, 66.7, and 83.3%, each, respectiv ely. At a concentration of 1mg/ g/day, dichloromethane, ethyl acetate, methanol total, wa ter, hexane extracts were effective in 33.3 each, 83.3 each and 66.7% of the cases respectively, while m ethanol successive extract at a dose of less than 500 mg/kg/ day did not cure any mice . Metronidazole at a concentration of 125mg/kg / day h ad a curative ra te of 100%. S everity of caecal wall ulceration reduced in mice which received extract s an d metronidazole compared to negative control animals