Effect of Amitraz on the Nervous System of Rats

Abstract

Female were Arm used albino to rats evaluatet rats .. The to characterize system the areas of the cerebral spinal cord; and that in the and animals phosphate their brain stem and Amitraz (P<O.01) and with were that ce11 sin the brain stem and morphological given by tap transcardial excised body the cerebral cord the weight(BW) were controls after six weeks. after 2 and treatment of ratio was cortex cerebellum,- and'processed BrW/BW the control (P<0.001). Animals the brain in grams The differences and using paraformaldehyde of significantly of those fed on 20 mg/kg The for microscopy.The were weeks perfusion sampled by light six body water. and weighed; rats groups of treated plain for brains treated weeks of treatment water (2%)- from 4 weeks and 20mg/kg glutaraldehyde spinal to 4, and 6 weeks. Tested gross of identify associated 10mg/kg drinking were examination Compared months toxicant innerve induces received in grams/ calculated , Tissues histological to by the cerebellum,Amitraz rats buffered weight(BrW) were study 1 changes sacrificed (2%) pH 7.24; the 4-5potential alterations in their control were study is altered cortex, rats of Amitraz the from brain. Experimental weight this that structura in age neurotoxicity nervous The hypotheses Amitraz causes changes the ob j e c t ive s of whether the nervous exposure. Ranging found different between were (P<0.01), Differences 10mg/kg ratios significant and between significant after the after 6 two ,iv Animals muscle treated weakness and treatment. The uncontrolled impulse acetylcholine at inhibits the was found in the of by the swelling of to accumulation as drug of of by of Amitraz Amitraz by decrease animals, the ingested sect ions of astrocytes effect from the and the neurons chromatolysis. That the concentrations used in this need recaut ions results exercise warned of the dangers studies caused as evidenced treated suggest to weekschool inesterase. Cells amount 6 junctions enzyme, of afterdue exposure. Examinat ion brain stem revealed The transmission cells generalized probably neuromuscular being determined displayed were brain displayed tremors tremors to destroy of musclejunctional number duration with 20 mg/kg are Amitraz would needed have it could Am i t ra z study. Or cause the Therefore users the there need if ingested. so as to determine on man.;s neurotoxic exact to at is be Further effect