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Browsing by Author "Obala, Andrew A."

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845. Children with clinical plasmodium falciparum infection have increased sharing of haplotypes with household members as well as temporally proximal, symptomatic peers

Cody, Nelson; Sumner, Kelsey; Betsy, Freedman; Obala, Andrew A.; Mangeni, Jane; Taylor, Steve; O'Meara, Wendy (Oxford academic journals, 2019)

Background Falciparum malaria transmission has failed to decline in proportion to control efforts in certain regions such as Bungoma county, western Kenya. One proposed strategy to eradicate malaria is ring testing and ...
bistro: An R package for vector bloodmeal identification by short tandem repeat overlap

Lapp, Zena; Abel, Lucy; Mangeni, Judith N.; Obala, Andrew A.; O’Meara, Wendy; Taylor, Steve M.; Markwalter, Christine F. (medRxiv, 2023)

Measuring vector-human contact in a natural setting can inform precise targeting of interventions to interrupt transmission of vector-borne diseases. One approach is to directly match human DNA in vector bloodmeals to the ...
Characterizing mobility patterns and malaria risk factors in semi-nomadic populations of Northern Kenya

Meredith, Hannah R.; Wesolowski, Amy; Okoth, Dennis; Maraga, Linda; Ambani, George; Chepkwony, Tabitha; Abel, Lucy; Kipkoech, Joseph; Lokoel, Gilchrist; Esimit, Daniel; Lokemer, Samuel; Maragia, James; Prudhomme O’Meara, Wendy; Obala, Andrew A. (PLOS ONE, 2024-03-13)

While many studies have characterized mobility patterns and disease dynamics of settled populations, few have focused on more mobile populations. Highly mobile groups are often at higher disease risk due to their regular ...
Epidemiology of Plasmodium falciparum infections in a Semi-Arid Rural African setting: Evidence from reactive case detection in Northwestern Kenya

Obala, Andrew A. (ASTMH, 2021)

In northwestern Kenya, Turkana County has been historically considered unsuitable for stable malaria transmission because of its unfavorable climate and predominantly semi-nomadic population; consequently, it is overlooked ...
Exploring how space, time, and sampling impact our ability to measure genetic structure across Plasmodium falciparum populations

Taylor, Steve M.; Arambepola, Rohan; Bérubé, Sophie; Freedman, Betsy; O’Meara, Wendy Prudhomme; Obala, Andrew A.; Wesolowski, Amy (Frontiers, 2023)

A primary use of malaria parasite genomics is identifying highly related infections to quantify epidemiological, spatial, or temporal factors associated with patterns of transmission. For example, spatial clustering of ...
Mosquito exposure and malaria morbidity: a microlevel analysis of household mosquito populations and malaria in a population-based longitudinal cohort in Western Kenya

O’Meara, Wendy Prudhomme; Simmons, Ryan; Bullins, Paige; Freedman, Betsy; Abel, Lucy; Mangeni, Judith; Taylor, Steve M.; Obala, Andrew A. (Oxford, 2019)

Background Malaria morbidity is highly overdispersed in the population. Fine-scale differences in mosquito exposure may partially explain this heterogeneity in individual malaria outcomes. Methods In 38 households we ...
Multiple cardiovascular risk factors in Kenya: evidence from a health and demographic surveillance system using the WHO stewise Aapproach to chronic disease risk factor surveillance

Bloomfield, Gerald S.; Mwangi, Ann; Chege, Patrick; Simiyu, Chrispinus J.; Daniel F., Aswa; Odhiambo, David; Obala, Andrew A.; Ayuo, Paul; Khwa-Otsyula, Barasa O. (NIH Public Access, 2013-07)

Objective—To describe the distribution of cardiovascular risk factors in western Kenya using a Health and Demographic Surveillance System (HDSS). Design—Population-based survey of residents in an HDSS Setting—Webuye ...
Plasmodium falciparum Genetic Diversity in Coincident Human and Mosquito Hosts

Prudhomme-O’Meara, Wendy; Zena, Lapp; Obala, Andrew A.; Abel, Lucy (mBio, 2022)

Population genetic diversity of Plasmodium falciparum antigenic loci is high despite large bottlenecks in population size during the parasite life cycle. The prevalence of genetically distinct haplotypes at these loci, ...
Plasmodium falciparum importation does not sustain malaria transmission in a semi-arid region of Kenya

MarkwalterI, Christine F.; Menya, Diana; Wesolowski, Amy; Esimit, Daniel; Lokoel, Gilchrist; Kipkoech, Joseph; Freedman, Elizabeth; Sumner, Kelsey M.; Abel, Lucy; Ambani, George; Meredith, Hannah R.; Taylor, Steve M.; Obala, Andrew A.; O’Meara, Wendy P. (PLOS Global Public Health, 2022-08-10)

Human movement impacts the spread and transmission of infectious diseases. Recently, a large reservoir of Plasmodium falciparum malaria was identified in a semi-arid region of northwestern Kenya historically considered ...
Risk of malaria following untreated sub-patent Plasmodium falciparum infections: Results over 4 years from a cohort in a high transmission area in Western Kenya

Zeno, Erica E.; Obala, Andrew A.; Pence, Brian; Freedman, Elizabeth; Mangeni, Judith N.; Lin, Jessica T.; Abel, Lucy; Edwards, Jessie K.; Gower, Emily W.; Taylor, Steve M. (Oxford academic journals, 2023)

Background: People with suspected malaria may harbor Plasmodium falciparum undetected by rapid diagnostic test (RDT). The impact is not fully understood of these sub-patent infections on the risk of developing clinical ...
Ristro: An R package for vector bloodmeal identification by short tandem repeat overlap

Lapp, Zena; Abel, Lucy; Mangeni, Judith; Obala, Andrew A.; O'Meara, Wendy P.; Taylor, Steve M.; Markwalter, Christine F. (John Wiley & Sons Ltd, 2024-12-03)

Measuring vector–human contact in a natural setting can inform precise target- ing of interventions to interrupt transmission of vector-borne diseases. One ap- proach is to directly match human DNA in vector bloodmeals ...
Superinfection plays an important role in the acquisition of complex Plasmodium falciparum infections among female Anopheles mosquitoes

Bérubé, Sophie; Freedman, Betsy; Menya, Diana; Kipkoech, Joseph; Abel, Lucy; Lapp, Zena; Taylor, Steve M.; O’Meara, Wendy Prudhomme; Obala, Andrew A.; Wesolowski, Amy (Biorxiv, 2022-12-07)

Studies of human malaria infections with multiple, genetically distinct parasites have illuminated mechanisms of malaria transmission. However, few studies have used the genetic diversity in mosquito infections to understand ...
What is threatening the effectiveness of insecticide-treated bednets? A case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A.; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy (Public Library of Science, 2015)

Background Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resurgence in malaria following successful ...
What Is threatening the effectiveness of insecticide-treated bednets? a case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A.; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; O'Meara, Wendy Prudhomme (PLOS ONE, 2015)

Background Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resurgence in malaria following successful ...
What is threatening the effectiveness of insecticide-treated bednets? A case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A.; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; O'Meara, Wendy Prudhomme (PLOS ONE, 2015-07-14)

Background Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resur- gence in malaria following ...
What is threatening the effectiveness of insecticide-treated bednets? A case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A.; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; O'Meara, Wendy Prudhomme (2015-07-14)

Background Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resurgence in malaria following successful ...
What Is Threatening the Effectiveness of Insecticide-Treated Bednets? A Case-Control Study of Environmental, Behavioral, and Physical Factors Associated with Prevention Failure

Obala, Andrew A.; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; O'Meara, Wendy Prudhomme (PLOS ONE, 2015-07-14)

RESEARCH ARTICLE What Is Threatening the Effectiveness of Insecticide-Treated Bednets? A Case-Control Study of Environmental, Behavioral, and Physical Factors Associated with Prevention Failure Andrew A. Obala1 , ...
What is threatening the effectiveness of insecticide-treated bednets? a case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A.; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; O'Meara, Wendy Prudhomme (PLOS ONE, 2015)

Background Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resurgence in malaria following successful ...

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