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Browsing by Author "Obala, Andrew A"

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Establishing Webuye Health and Demographic Surveillance Site in Rural Western Kenya: Challenges and Lessons Learned

Simiyu, Chrispinus J; Naanyu, Violet; Obala, Andrew A; Odhiambo, David O; Ayuo, Paul; Chelagat, Dinah; Downing, Raymond; Menya, Diana; Mwaliko, Emily; Omeara, Wendy P.; Were, Edwin O; Marc, Twagirumukiza; Broeck, Davy Vanden; Shitote, Stanley; Maeseneer, Jan De; Khwa-Otsyula, Barasa O (Hindawi, 2013-04)

This paper describes the methodologies, challenges and lessons learned in establishing Webuye Health and Demographic Surveillance System (HDSS) in Webuye Division of Bungoma County. The Webuye HDSS was established in ...
Exposure to diverse Plasmodium falciparum Genotypes shapes the Risk of Symptomatic Malaria in incident and persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya

Mangeni, Judith N; Obala, Andrew A; Lucy, Abel (Oxford University Press for the Infectious Diseases Society of America., 2021-10)

Abstract Background Repeated exposure to malaria infections could protect against symptomatic progression as people develop adaptive immunity to infections acquired over time. Methods We investigated how new, ...
Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya

Sumner, Kelsey M; Mangeni, Judith N; Obala, Andrew A; Steven, Lucy Abel,; Edwards, Jessie K (2021-07)

Background: Asymptomatic Plasmodium falciparum infections are common in sub-Saharan Africa, but their effect on subsequent symptomaticity is incompletely understood. Methods: In a 29-month cohort of 268 people in ...
Mosquito and human characteristics influence natural Anopheline biting behavior and Plasmodium falciparum transmission

Markwalter, Christine F; Lapp, Zena; Abel, Lucy; Kimachas, Emmah; Omollo, Evans; Freedman, Elizabeth; Chepkwony, Tabitha; Amunga, Mark; McCormick, Tyler; Bérubé, Sophie; Mangeni, Judith N; Wesolowski, Amy; Obala, Andrew A; Taylor, Steve M T; O’Meara, Wendy P (medRxiv, 2024-01-25)

The human infectious reservoir of malaria Plasmodium falciparum parasites is governed by the efficiency of parasite transmission during vector human contact as well as mosquito biting preferences. Understanding mosquito ...
Multiple cardiovascular risk factors in Kenya: evidence from a health and demographic surveillance system using the WHO STEPwise approach to chronic disease risk factor surveillance

Bloomfield, Gerald S; Mwangi, Ann; Chege, Patrick; Simiyu, Chrispinus J; Aswa, Daniel F; Odhiambo, David; Obala, Andrew A; Ayuo, Paul; Khwa-Otsyula, Barasa O (BMJ Publishing Group Limited., 2013)

Objective To describe the distribution of cardiovascular risk factors in western Kenya using a Health and Demographic Surveillance System (HDSS). Design Population based survey of residents in an HDSS. Setting Webuye ...
Plasmodium falciparum genetic diversity in coincident human and mosquito hosts

Lapp, Zena; Obala, Andrew A; Abel, Lucy; Rasmussen, David A; Sumner, Kelsey M.; Freedman, Elizabeth; Taylor, Steve M; Prudhomme-O’Meara, Wendy (American society of microbiology, 2022-07-08)

Population genetic diversity of Plasmodium falciparum antigenic loci is high despite large bottlenecks in population size during the parasite life cycle. The prevalence of genetically distinct haplotypes at these loci, ...
Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites

Markwalter, Christine F.; Petersen, Jens E. V; Zeno, Erica E; Sumne, Kelsey M; Freedman, Elizabeth; Mangen, Judith N.; Abel, Lucy; Obala, Andrew A; Prudhomme-O’Meara, Wendy; Taylor, Steve M. (PLOS ONE, 2022-06-12)

A signature remains elusive of naturally-acquired immunity against Plasmodium falciparum. We identified P. falciparum in a 14-month cohort of 239 people in Kenya, genotyped at immunogenic parasite targets expressed in ...
What is threatening the effectiveness of insecticide-treated bednets? A case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; O'Meara, Wendy Prudhomme (PLOS ONE, 2015-07-14)

Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resur- gence in malaria following successful control. ...
What Is threatening the effectiveness of insecticide-treated bednets? A case-control study of environmental, behavioral, and physical factors associated with prevention failure

Obala, Andrew A; Mangeni, Judith Nekesa; Platt, Alyssa; Aswa, Daniel; Abel, Lucy; Namae, Jane; Prudhomme O'Meara, Wendy (PLOS ONE, 2015-07-14)

Background Insecticide-treated nets are the cornerstone of global malaria control and have been shown to reduce malaria morbidity by 50–60%. However, some areas are experiencing a resur- gence in malaria following ...

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