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http://ir.mu.ac.ke:8080/jspui/handle/123456789/9550| Title: | Vincristine exposure in Kenyan children with cancer: CHAPATI feasibility study |
| Authors: | Uittenboogaard, Aniek Velde, Mirjam van de Heijden, Lisa van de Mukuhi, Leah Vries, Niels de Langat, Sandra Olbara, Gilbert Huitema, Alwin D. R Vik, Terry Kaspers, Gertjan Njuguna, Festus |
| Keywords: | Individualized dosing, Pediatric oncology Pharmacokinetics Vincristine |
| Issue Date: | 10-Jun-2024 |
| Publisher: | Wiley |
| Abstract: | The low incidence of vincristine-induced peripheral neuropathy (VIPN) in Kenyan children may result from low vincristine exposure. We studied vincristine expo- sure in Kenyan children and dose-escalated in case of low vincristine exposure (NCT05844670). Average vincristine exposure was high. Individual vincristine expo- sure was assessed with a previously developed nomogram. A 20% dose increase was recommended for participants with low exposure and no VIPN, hyperbilirubinemia, or malnutrition. None of the 15 participants developed VIPN. Low vincristine exposure was seen in one participant: a dose increase was implemented without side effects. In conclusion, the participants did not develop VIPN despite having high vincristine exposure. |
| URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/9550 |
| Appears in Collections: | School of Medicine |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| festus njuguna.pdf | 378.67 kB | Adobe PDF | View/Open |
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