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http://ir.mu.ac.ke:8080/jspui/handle/123456789/9227
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DC Field | Value | Language |
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dc.contributor.author | Markwalter, Christine F. | - |
dc.contributor.author | Lapp, Zena | - |
dc.contributor.author | Abel, Lucy | - |
dc.contributor.author | Kimachas, Emmah | - |
dc.contributor.author | Omollo, Evans | - |
dc.contributor.author | Freedman, Elizabeth | - |
dc.contributor.author | Chepkwony, Tabitha | - |
dc.contributor.author | Amunga, Mark | - |
dc.contributor.author | McCormick, Tyler | - |
dc.contributor.author | Bérubé, Sophie | - |
dc.contributor.author | Mangeni, Judith N. | - |
dc.contributor.author | Wesolowski, Amy | - |
dc.contributor.author | Obala, Andrew A. | - |
dc.contributor.author | Taylor, Steve M. | - |
dc.contributor.author | O’Meara, Wendy Prudhomme | - |
dc.date.accessioned | 2024-06-10T07:07:00Z | - |
dc.date.available | 2024-06-10T07:07:00Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/9227 | - |
dc.description.abstract | The human infectious reservoir of Plasmodium falciparum is governed by transmission efficiency during vector-human contact and mosquito biting preferences. Understanding biting bias in a natural setting can help target interventions to interrupt transmission. In a 15-month cohort in western Kenya, we detected P. falciparum in indoor-resting Anopheles and human blood samples by qPCR and matched mosquito bloodmeals to cohort participants using short-tandem repeat genotyping. Using risk factor analyses and discrete choice models, we assessed mosquito biting behavior with respect to parasite transmission. Biting was highly unequal; 20% of people received 86% of bites. Biting rates were higher on males (biting rate ratio (BRR): 1.68; CI: 1.28–2.19), children 5–15 years (BRR: 1.49; CI: 1.13–1.98), and P. falciparuminfected individuals (BRR: 1.25; CI: 1.01–1.55). In aggregate, P. falciparuminfected school-age (5–15 years) boys accounted for 50% of bites potentially leading to onward transmission and had an entomological inoculation rate 6.4x higher than any other group. Additionally, infectious mosquitoes were nearly 3x more likely than non-infectious mosquitoes to bite P. falciparuminfected individuals (relative risk ratio 2.76, 95% CI 1.65–4.61). Thus, persistent P. falciparum transmission was characterized by disproportionate onward transmission from school-age boys and by the preference of infected mosquitoes to feed upon infected people. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Plasmodium falciparum infection | en_US |
dc.title | Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
Files in This Item:
File | Description | Size | Format | |
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Plasmodium_falciparum_infection_in_humans_and_mosq (2).pdf | 1.02 MB | Adobe PDF | View/Open |
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