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DC Field | Value | Language |
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dc.contributor.author | Nyamogoba, H. D. N | - |
dc.contributor.author | Kikuvi, G. | - |
dc.contributor.author | Mpoke, S. | - |
dc.contributor.author | Waiyaki, P. G. | - |
dc.contributor.author | Soolingen, D. Van | - |
dc.date.accessioned | 2024-05-27T07:11:16Z | - |
dc.date.available | 2024-05-27T07:11:16Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/9140 | - |
dc.description.abstract | Objective: To determine the accuracy of Ziehl-Neelsen microscopy in the diagnosis of TB in setings of high HIV prevalence. Design: Cross-sectional descriptive study. Setting: Hospitals serving areas of high human immunodeficiency virus prevalence in western Kenya. The study was conducted between September 2007 and September 2009. Results: In total, 341/872 (39.1%) of the TB suspects were positive in ZN, 53.1% (181/341) of them culture positive. Only 3.8% (20/531) of the ZN smear negatives were culture positive. Of the 695 suspects evaluated for both Mycobacterium and HIV infection, 255 (36.7%) were ZN smear positive, 42.7% of them HIV positive. Out of the 440 ZN smear negatives, 37% were HIV positive. Similarly, 168 suspects were culture positive, 46.4% of them HIV positive. The HIV infection did not significantly reduce ZN smear positivity rate (P = 0.42) and culture sensitivity (P = 0.09). The ZN sensitivity and specificity were 88.1% and 79.7%, respectively. The predictive values were 58.0 (PPV), and 95.5% (NPV), respectively. However, the area under the ROC curve was 0.84, with 95% CI between 0.80-0.87 and P< 0.001). The ZN smear microscopy had a lesser ability to distinguish between TB and non-TB cases compared to culture. Conclusion: ZN microscopy causes a significant over-diagnosis of TB in settings of high HIV/AIDS prevalence. There is need for further studies on this subject taking into consideration the various confounding factors. | en_US |
dc.language.iso | en | en_US |
dc.publisher | East African Medical journal | en_US |
dc.subject | Ziehl-Neelsen microscopy | en_US |
dc.subject | TB | en_US |
dc.subject | HIV prevalence. | en_US |
dc.title | Ziehl-neelsen microscopy in the diagnosis of tuberculosis in settings of high human immunodeficiency virus prevalence | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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File | Description | Size | Format | |
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NYAMAGOBA.pdf | 320.35 kB | Adobe PDF | View/Open |
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