Please use this identifier to cite or link to this item: http://ir.mu.ac.ke:8080/jspui/handle/123456789/9119
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dc.contributor.authorZhang, Jianjun-
dc.contributor.authorOrang’o, Omenge-
dc.contributor.authorTonui, Philip-
dc.contributor.authorTong, Yan-
dc.contributor.authorMaina, Titus-
dc.contributor.authorKiptoo, Stephen-
dc.contributor.authorKatpen Muthoka, Katpen-
dc.contributor.authorGroopman, John-
dc.contributor.authorSmith, Joshua-
dc.contributor.authorMadeen, Erin-
dc.contributor.authorErmel, Aaron-
dc.contributor.authorLoehrer, Patrick-
dc.contributor.authorR. Brown, Darron-
dc.date.accessioned2024-05-22T12:06:59Z-
dc.date.available2024-05-22T12:06:59Z-
dc.date.issued2019-08-05-
dc.identifier.urihttp://ir.mu.ac.ke:8080/jspui/handle/123456789/9119-
dc.description.abstractackground. Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillo- mavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor. Methods. Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus- uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration. Results. Valid HPV testing results were available for 86 women (mean age 34.0 years); 49 women (57.0%) had AFB1-lys detected and 37 (43.0%) had none. The AFB1-lys detection was not associated with age, being married, having more than secondary school education, home ownership, living at a walking distance to healthcare ≥60 minutes, number of lifetime sex partners, or age of first sex. The AFB1-lys detection and plasma concentrations were associated with detection of oncogenic HPV types. Conclusions. The AFB1-lys positivity and higher plasma AFB1-lys concentrations were associated with higher risk of oncogenic HPV detection in cervical samples from Kenya women. Further studies are needed to determine whether aflatoxin interacts with HPV in a synergistic manner to increase the risk of cervical canceren_US
dc.description.sponsorship1U54CA190151-01en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectAflatoxinen_US
dc.subjectKenyan womenen_US
dc.subjectOncogenic human papillomavirusen_US
dc.titleDetection and Concentration of Plasma Aflatoxin Is Associated With Detection of Oncogenic Human Papillomavirus in Kenyan Womenen_US
dc.typeArticleen_US
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