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http://ir.mu.ac.ke:8080/jspui/handle/123456789/9119
Title: | Detection and Concentration of Plasma Aflatoxin Is Associated With Detection of Oncogenic Human Papillomavirus in Kenyan Women |
Authors: | Zhang, Jianjun Orang’o, Omenge Tonui, Philip Tong, Yan Maina, Titus Kiptoo, Stephen Katpen Muthoka, Katpen Groopman, John Smith, Joshua Madeen, Erin Ermel, Aaron Loehrer, Patrick R. Brown, Darron |
Keywords: | Aflatoxin Kenyan women Oncogenic human papillomavirus |
Issue Date: | 5-Aug-2019 |
Publisher: | Oxford University Press |
Abstract: | ackground. Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillo- mavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor. Methods. Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus- uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration. Results. Valid HPV testing results were available for 86 women (mean age 34.0 years); 49 women (57.0%) had AFB1-lys detected and 37 (43.0%) had none. The AFB1-lys detection was not associated with age, being married, having more than secondary school education, home ownership, living at a walking distance to healthcare ≥60 minutes, number of lifetime sex partners, or age of first sex. The AFB1-lys detection and plasma concentrations were associated with detection of oncogenic HPV types. Conclusions. The AFB1-lys positivity and higher plasma AFB1-lys concentrations were associated with higher risk of oncogenic HPV detection in cervical samples from Kenya women. Further studies are needed to determine whether aflatoxin interacts with HPV in a synergistic manner to increase the risk of cervical cancer |
URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/9119 |
Appears in Collections: | School of Medicine |
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