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Title: | Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study |
Authors: | Navuluri, Neelima Lagat, David Egger, Joseph R. Birgen, Elcy Diero, Lameck Murdoch, David M. Thielman, Nathan Kussin, Peter S. Que, Loretta G. Paul, Devon |
Keywords: | Asthma Airflow obstruction Eosinophilic airway inflammation |
Issue Date: | 17-Aug-2023 |
Publisher: | IJPH |
Abstract: | Objectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life. Methods: A three-stage, cluster-randomized cross-sectional study in Uasin Gishu County, Kenya was conducted. Individuals 12 years and older completed questionnaires (including St. George’s Respiratory Questionnaire for COPD, SGRQ-C), spirometry, and fractional exhaled nitric oxide (FeNO) testing. Prevalence ratios with 95% confidence intervals (CIs) were calculated. Multivariable models were used to assess correlates of airflow obstruction and high FeNO. Results: Three hundred ninety-two participants completed questionnaires, 369 completed FeNO testing, and 305 completed spirometry. Mean age was 37.5 years; 64% were women. The prevalence of asthma, airflow obstruction on spirometry, and eosinophilic airway inflammation was 21.7%, 12.3% and 15.7% respectively in the population. Women had significantly higher SGRQ-C scores compared to men (15.0 vs. 7.7). Wheezing or whistling in the last year and SGRQ-C scores were strongly associated with FeNO levels >50 ppb after adjusting for age, gender, BMI, and tobacco use. Conclusion: Airway disease is a significant health problem in Kenya affecting a young population who lack a significant tobacco use history. |
URI: | https://doi.org/10.3389/ijph.2023.1606030 http://ir.mu.ac.ke:8080/jspui/handle/123456789/9070 |
Appears in Collections: | School of Medicine |
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