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Title: | No differences between lopinavir/ritonavir and nonnucleoside reverse transcriptase inhibitor–based an- tiretroviral therapy on clearance of plasmodium falciparum subclinical parasitemia in adults living with HIV starting treatment (A5297 |
Authors: | Shaffer, Douglas Kumwenda, Johnstone Chen, Huichao Akelo, Victor Angira, Francis Kosgei, Josphat Tonui, Ronald Ssali, Francis McKhann, Ashley Hogg, Evelyn Stewart, V. Ann Murphy, Sean C. Coombs, Robert Schooley, Robert |
Keywords: | Malaria Subclinical parasitemi HIV ART Protease inhibitors |
Issue Date: | 1-Mar-2021 |
Publisher: | Wolters Kluwer Health, Inc. |
Abstract: | Background: HIV protease inhibitors anti-Plasmodium falcipa- rum activity in adults remains uncertain. Methods: Adults with HIV CD4+ counts .200 cells/mm3 starting antiretroviral therapy (ART) with P. falciparum subclinical para- sitemia (Pf SCP) were randomized 1:1 to (step 1) protease inhibitor lopinavir/ritonavir (LPV/r)-based (arm A) or nonnucleoside reverse transcriptase inhibitor (nNRTI)-based ART (arm B) for 15 days. In step 2, participants received nNRTI-based ART and trimethoprim/ sulfamethoxazole prophylaxis for 15 days. P. falciparum SCP clearance was measured by polymerase chain reaction. The Fisher exact test [95% exact confidence interval (CI)] was used to compare proportions of P. falciparum SCP clearance (,10 parasites/mL on 3 occasions within 24 hours) between LPV/r and nNRTI arms at day 15. The Kaplan–Meier method and log-rank test were used to compare time-to-clearance. Results: Fifty-two adults from Kenya, Malawi, and Uganda with a median age = 31 (Q1, Q3: 24–39) years, 33% women, with baseline median CD4 + counts of 324 (259–404) cells/mm 3 , median HIV-1 RNA viremia of 5.18 log10 copies/mL (4.60–5.71), and median estimated P. falciparum density of 454 parasites/mL (83–2219) enrolled in the study. Forty-nine (94%) participants completed the study. At day 15, there was no statistically significant difference in the proportions of P. falciparum SCP clearance between the LPV/r (23.1% clearance; 6 of the 26) and nNRTI (26.9% clearance; 7 of the 26) arms [between-arm difference 3.9% (95% CI, 221.1% to 28.4%; P = 1.00)]. No significant difference in time-to-clearance was observed between the arms (P = 0.80). Conclusions: In a small randomized study of adults starting ART with P. falciparum SCP, no statistically significant differences were seen between LPV/r- and nNRTI-based ART in P. falciparum SCP clearance after 15 days of treatment. |
URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/8098 |
Appears in Collections: | School of Medicine |
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