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DC Field | Value | Language |
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dc.contributor.author | Markwalter, Christine F. | - |
dc.contributor.author | Petersen, Jens E. V | - |
dc.contributor.author | Zeno, Erica E | - |
dc.contributor.author | Sumne, Kelsey M | - |
dc.contributor.author | Freedman, Elizabeth | - |
dc.contributor.author | Mangen, Judith N. | - |
dc.contributor.author | Abel, Lucy | - |
dc.contributor.author | Obala, Andrew A | - |
dc.contributor.author | Prudhomme-O’Meara, Wendy | - |
dc.contributor.author | Taylor, Steve M. | - |
dc.date.accessioned | 2023-06-26T07:01:56Z | - |
dc.date.available | 2023-06-26T07:01:56Z | - |
dc.date.issued | 2022-06-12 | - |
dc.identifier.uri | https://doi.org/10.1371/journal. ppat.1011442 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/7638 | - |
dc.description.abstract | A signature remains elusive of naturally-acquired immunity against Plasmodium falciparum. We identified P. falciparum in a 14-month cohort of 239 people in Kenya, genotyped at immunogenic parasite targets expressed in the pre-erythrocytic (circumsporozoite protein, CSP) and blood (apical membrane antigen 1, AMA-1) stages, and classified into epitope type based on variants in the DV10, Th2R, and Th3R epitopes in CSP and the c1L region of AMA-1. Compared to asymptomatic index infections, symptomatic malaria was associated with reduced reinfection by parasites bearing homologous CSP-Th2R (adjusted hazard ratio [aHR]:0.63; 95% CI:0.45–0.89; p = 0.008) CSP-Th3R (aHR:0.71; 95% CI:0.52–0.97; p = 0.033), and AMA-1 c1L (aHR:0.63; 95% CI:0.43–0.94; p = 0.022) epitope types. The asso- ciation of symptomatic malaria with reduced hazard of homologous reinfection was stron- gest for rare epitope types. Symptomatic malaria provides more durable protection against reinfection with parasites bearing homologous epitope types. The phenotype represents a legible molecular epidemiologic signature of naturally-acquired immunity by which to identify new antigen targets. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PLOS ONE | en_US |
dc.subject | Plasmodium falciparum. | en_US |
dc.subject | Malaria | en_US |
dc.subject | Immunogenic parasite | en_US |
dc.title | Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Public Health |
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