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http://ir.mu.ac.ke:8080/jspui/handle/123456789/7638
Title: | Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites |
Authors: | Markwalter, Christine F. Petersen, Jens E. V Zeno, Erica E Sumne, Kelsey M Freedman, Elizabeth Mangen, Judith N. Abel, Lucy Obala, Andrew A Prudhomme-O’Meara, Wendy Taylor, Steve M. |
Keywords: | Plasmodium falciparum. Malaria Immunogenic parasite |
Issue Date: | 12-Jun-2022 |
Publisher: | PLOS ONE |
Abstract: | A signature remains elusive of naturally-acquired immunity against Plasmodium falciparum. We identified P. falciparum in a 14-month cohort of 239 people in Kenya, genotyped at immunogenic parasite targets expressed in the pre-erythrocytic (circumsporozoite protein, CSP) and blood (apical membrane antigen 1, AMA-1) stages, and classified into epitope type based on variants in the DV10, Th2R, and Th3R epitopes in CSP and the c1L region of AMA-1. Compared to asymptomatic index infections, symptomatic malaria was associated with reduced reinfection by parasites bearing homologous CSP-Th2R (adjusted hazard ratio [aHR]:0.63; 95% CI:0.45–0.89; p = 0.008) CSP-Th3R (aHR:0.71; 95% CI:0.52–0.97; p = 0.033), and AMA-1 c1L (aHR:0.63; 95% CI:0.43–0.94; p = 0.022) epitope types. The asso- ciation of symptomatic malaria with reduced hazard of homologous reinfection was stron- gest for rare epitope types. Symptomatic malaria provides more durable protection against reinfection with parasites bearing homologous epitope types. The phenotype represents a legible molecular epidemiologic signature of naturally-acquired immunity by which to identify new antigen targets. |
URI: | https://doi.org/10.1371/journal. ppat.1011442 http://ir.mu.ac.ke:8080/jspui/handle/123456789/7638 |
Appears in Collections: | School of Public Health |
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