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Title: | Severe abacavir hypersensitivity reaction in a patient with human immunodeficiency virus infection: a case report |
Authors: | Koech, Mathew K. Ali, Shamim M. Karoney, Mercy J. Kigen, Gabriel |
Keywords: | Hypersensitivity HIV |
Issue Date: | 2022 |
Publisher: | BMC |
Abstract: | Abacavir is a nucleoside reverse transcriptase inhibitor that is used as a component of the antiretroviral treatment regimen in the management of the human immunodeficiency virus for both adults and children. It is efficacious, but its use may be limited by a hypersensitivity reaction linked with the HLA-B*57:01 genotype. HLA-B*57:01 has been reported to be rare in African populations. Because of the nature of its presentation, abacavir hypersensitivity is prone to late diagnosis and treatment, especially in settings where HLA-B*57:01 genotyping is not routinely done. |
URI: | https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-022-03647-6 http://ir.mu.ac.ke:8080/jspui/handle/123456789/7632 |
Appears in Collections: | School of Medicine |
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