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http://ir.mu.ac.ke:8080/jspui/handle/123456789/7123
Title: | Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya |
Authors: | Peprah, Sally D. Ogwang, Martin Kerchan, Patrick J. Reynolds, Steven N. Tenge, Constance A. Were, Pamela T. Kuremu, Robert N Wekesa, Walter Masalu, Nestory Kawira, Esther Kinyera, Tobias Otim, Isaac Legason D., Ismail Nabalende, Hadijah Dhudha, Herry Mumia, Mediatrix Ayers, Leona W. Biggar, Robert J. Bhatia, Kishor Goedert, James J. Mbulaiteye, Sam M. |
Keywords: | Burkitt lymphoma Epidemiology Epstein–Barr virus, non- Hodgkin lymphoma Plasmodium falciparum malaria Platelet counts. |
Issue Date: | 12-May-2020 |
Publisher: | John Wiley & Sons Ltd |
Abstract: | Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2 248 controls enrolled in a case-control study in Uganda, Tanzania and Kenya (2010–2016). Mean platelet counts in con- trols or eBL cases with or without malaria-infection in controls versus eBLcases were compared using Student’s t-test. Odds ratios (ORs) and two-sided 95% confidence intervals (95% CIs) were estimated using multi- ple logistic regression, controlling for age, sex, haemoglobin and white blood cell counts. Platelets were decreased with malaria infection in the controls [263 vs. 339 9 10 9 platelets/l, P < 0 0001; adjusted OR (aOR) = 3 42, 95% CI: 2 79–4 18] and eBL cases (314 vs. 367 9 109 plate- lets/l, P-value = 0 002; aOR = 2 36, 95% CI: 1 49–3 73). Unexpectedly, pla- telets were elevated in eBL cases versus controls in overall analyses (mean: 353 vs. 307 9 10 9 platelets/l, P < 0 0001; aOR = 1 41; 95% CI: 1 12–1 77), and when restricted to malaria-positive (mean 314 vs. 263 9 109 platelets/ l, P < 0 0001; OR = 2 26; 95% CI: 1 56–3 27) or malaria-negative (mean 367 vs. 339 9 10 9 platelets/l, P < 0 001; OR = 1 46; 95% CI: 1 17–1 83) subjects. Platelets were decreased with malaria infection in controls and eBL cases but elevated with eBL. |
URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/7123 |
Appears in Collections: | School of Medicine |
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