The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientifc knowledge and data compiled and critically evaluated by an overarching science–policy inter‑ face body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems think‑ ing. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientifc networks and to intensify science–policy interaction with national governments to support the nego‑ tiations on the establishment of an intergovernmental body based on scientifc knowledge explaining the anticipated beneft for human and environmental health.

Abstract

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientifc knowledge and data compiled and critically evaluated by an overarching science–policy inter‑ face body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientifc networks and to intensify science–policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientifc knowledge explaining the anticipated beneft for human and environmental health.