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Title: | CD34-Negative B-Lymphoblastic leukemia/lymphoma presenting as cutenous lesions at infancy: a case report |
Authors: | Lotodo1, Teresa Njuguna, Festus Kiprono, Samson Olbara, Gilbert Kigen, Nicholas |
Keywords: | Lymphoblastic Leukemia Flow Cytometry CD34 Negative Cutaneous Lesions Infancy |
Issue Date: | Apr-2022 |
Publisher: | Scientific research publishing |
Series/Report no.: | 10; |
Abstract: | Acute lymphoblastic leukemia/lymphoma is a highly aggressive neoplasm of precursor lymphoid (blast) cells. There are 2 main subtypes based on lymphoid lineage; B lymphoblastic leukemia/lymphoma (B-ALL/LBL) and T lymphoblastic leukemia/lymphoma (T-ALL/LBL). B-ALL/LBL commonly presents with fever, fatigue, bone or joint pain, bleeding or anorexia (signs of bone marrow infiltration), lymphadenopathy, hepatosplenomegaly, involvement of skin, soft tissue and testes, with a predilection for the central nervous system. Immature cell markers, such as CD34 and TdT, can help to differentiate lymphoblasts from Burkitt lymphoma which, is considered a mature high-grade B cell lymphoma that mimics lymphoblastic lymphoma/leukemia. Unfavorable prognostic factors include: infancy and adult age of diagnosis, high white blood cell count, slow response to initial therapy, central nervous system involvement at the time of diagnosis and Minimal residual disease after therapy. We present a case report of a 4 months old infant seen at a Tertiary Hospital with a rare presentation of CD34 Negative B-lymphoblastic leukemia/lymphoma presenting as cutaneous lesions in infancy. |
URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/6496 |
Appears in Collections: | School of Medicine |
Files in This Item:
File | Description | Size | Format | |
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LOTODO.pdf | 5.81 MB | Adobe PDF | View/Open |
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