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DC Field | Value | Language |
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dc.date.accessioned | 2022-04-08T08:48:02Z | - |
dc.date.available | 2022-04-08T08:48:02Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/6228 | - |
dc.description.abstract | Alterations in the cytokine status have been suggested to be at least partly responsible for the immune tolerance during pregnancy. Indeed, interleukin-10 (IL-10) cytokine is known to control inflammation induced pathologies of pregnancy. The current study was set to investigate if HIV infection influences the production of IL-10 cytokine during pregnancy in adult asymptomatic HIV-infected pregnant women (n=44) and antiretroviral-naïve at enrolment as compared to controls (HIV non-infected pregnant women, n=44). Quantitative analysis of the IL-10 cytokines was done using Cytometry Bead Array Technology. Data analysis was performed using STATA version 13. P-value ≤0.05 was considered statistically significant. Results revealed differences in the mean of IL-10 cytokine levels between the HIV-positive and the HIV negative participants over time across trimesters; trimester one 1.5 [(95% CI: 0.4, 2.5), P=0.008], second trimester 1.0 [(95% CI: 0.2, 1.9), P=0.019], and third trimester 1.2 [(95% CI: 0.3, 2.1), P=0.009]. These results demonstrates that, HIV infection favor the up regulation of IL-10 cytokine production in pregnancy. This upregulation of IL-10 may control inflammation-induced pathologies due to HIV during pregnancy. Further insight into the complexity of IL-10 cytokine in both HIV infections and pregnancy is greatly recommended to enable novel development of therapeutic strategies using this cytokine and targeting HIV infected pregnant women | en_US |
dc.language.iso | en | en_US |
dc.publisher | IGM | en_US |
dc.subject | HIV infection | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Interleukin-10 | en_US |
dc.subject | Trimesters | en_US |
dc.title | Upregulation of peripheral blood levels of immune-regulatory Interleukin-10 Cytokine in human immunodeficiency virus-infected compared to non-infected pregnant women | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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MINING.pdf | 461.85 kB | Adobe PDF | View/Open |
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