Please use this identifier to cite or link to this item:
http://ir.mu.ac.ke:8080/jspui/handle/123456789/6200
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sumner, Kelsey M | - |
dc.contributor.author | Mangeni, Judith N | - |
dc.contributor.author | Obala, Andrew A | - |
dc.contributor.author | Steven, Lucy Abel, | - |
dc.contributor.author | Edwards, Jessie K | - |
dc.date.accessioned | 2022-04-04T09:48:15Z | - |
dc.date.available | 2022-04-04T09:48:15Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.uri | https://elifesciences.org/articles/68812 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/6200 | - |
dc.description.abstract | Background: Asymptomatic Plasmodium falciparum infections are common in sub-Saharan Africa, but their effect on subsequent symptomaticity is incompletely understood. Methods: In a 29-month cohort of 268 people in Western Kenya, we investigated the association between asymptomatic P. falciparum and subsequent symptomatic malaria with frailty Cox models. Results: Compared to being uninfected, asymptomatic infections were associated with an increased 1 month likelihood of symptomatic malaria (adjusted hazard ratio [aHR]: 2.61, 95% CI: 2.05 to 3.33), and this association was modified by sex, with females (aHR: 3.71, 95% CI: 2.62 to 5.24) at higher risk for symptomaticity than males (aHR: 1.76, 95% CI: 1.24 to 2.50). This increased symptomatic malaria risk was observed for asymptomatic infections of all densities and in people of all ages. Long-term risk was attenuated but still present in children under age 5 (29-month aHR: 1.38, 95% CI: 1.05 to 1.81). Conclusions: In this high-transmission setting, asymptomatic P. falciparum can be quickly followed by symptoms and may be targeted to reduce the incidence of symptomatic illness. | en_US |
dc.language.iso | en | en_US |
dc.subject | Plasmodium falciparum | en_US |
dc.subject | longitudinal cohort | en_US |
dc.title | Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Public Health |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.