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DC Field | Value | Language |
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dc.contributor.author | O’Meara, Wendy P | - |
dc.contributor.author | Mott, Joshua A | - |
dc.contributor.author | Laktabai, Jeremiah | - |
dc.contributor.author | Wamburu, Kabura | - |
dc.contributor.author | Fields, Barry | - |
dc.contributor.author | Armstrong, Janice | - |
dc.date.accessioned | 2022-03-28T12:00:09Z | - |
dc.date.available | 2022-03-28T12:00:09Z | - |
dc.date.issued | 2015-03-09 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/6149 | - |
dc.description.abstract | In Kenya, more than 10 million episodes of acute febrile illness are treated annually among children under 5 years. Most are clinically managed as malaria without parasitological confirmation. There is an unmet need to describe pathogen-specific etiologies of fever. We enrolled 370 febrile children and 184 healthy controls. We report demographic and clinical characteristics of patients with Plasmodium falciparum, group A streptococcal (GAS) pharyngitis, and respiratory viruses (influenza A and B, respiratory syncytial virus [RSV], parainfluenza [PIV] types 1–3, adenovirus, human metapneumovirus [hMPV]), as well as those with undifferentiated fever. Of febrile children, 79.7% were treated for malaria. However, P. falciparum was detected infrequently in both cases and controls (14/268 [5.2%] versus 3/133 [2.3%], P = 0.165), whereas 41% (117/282) of febrile children had a respiratory viral infection, compared with 24.8% (29/117) of controls (P = 0.002). Only 9/515 (1.7%) children had streptococcal infection. Of febrile children, 22/269 (8.2%) were infected with > 1 pathogen, and 102/275 (37.1%) had fevers of unknown etiology. Respiratory viruses were common in both groups, but only influenza or parainfluenza was more likely to be associated with symptomatic disease (attributable fraction [AF] 67.5% and 59%, respectively). Malaria was over diagnosed and over-treated. Few children presented to the hospital with GAS pharyngitis. An enhanced understanding of carriage of common pathogens, improved diagnostic capacity, and better-informed clinical algorithms for febrile illness are needed. | en_US |
dc.description.sponsorship | Duke Global Health Institute | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pubmed central | en_US |
dc.subject | Streptococcal pharyngitis | en_US |
dc.subject | Falciparum malaria | en_US |
dc.subject | Etiology | en_US |
dc.subject | Pediatric | en_US |
dc.title | Etiology of pediatric fever in Western Kenya: A case–control study of falciparum malaria, respiratory viruses,and streptococcal pharyngitis | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Public Health |
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