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DC Field | Value | Language |
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dc.contributor.author | Chang, Aileen Y. | - |
dc.contributor.author | Karwa, Rakhi | - |
dc.contributor.author | Odhiambo, Haji | - |
dc.contributor.author | Were, Phelix | - |
dc.contributor.author | Fletcher, Sara L. | - |
dc.contributor.author | Tonui, Edith C. | - |
dc.contributor.author | Kohn, Michael A. | - |
dc.contributor.author | Lee, Jeannette | - |
dc.contributor.author | Chang, Di | - |
dc.contributor.author | Lensing, Shelly | - |
dc.contributor.author | Namaemba, Diana Flora | - |
dc.contributor.author | Busakhala, Naftali | - |
dc.contributor.author | Kiprono, Samson K. | - |
dc.contributor.author | Maurer, Toby | - |
dc.contributor.author | Goodrich, suzanne | - |
dc.contributor.author | Pastakia, Sonak D. | - |
dc.date.accessioned | 2022-02-02T09:22:34Z | - |
dc.date.available | 2022-02-02T09:22:34Z | - |
dc.date.issued | 2022-02-02 | - |
dc.identifier.uri | DOI https://doi.org/10.1200/GO.21.00329. | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/5914 | - |
dc.description.abstract | bstract PURPOSE Evaluate the effectiveness of compression while receiving chemotherapy compared with chemo therapy alone in the treatment of HIV-associated Kaposi sarcoma (KS) lymphedema. METHODS A randomized controlled trial was conducted in a single oncology clinic in western Kenya (NCT03404297). A computer-generated randomization schedule was used to allocate treatment arms. Randomized block design was used for stratification by lymphedema stage. Participants were HIV positive adults age ≥ 18 years on antiretroviral therapy with biopsy-proven KS associated with leg lymphedema and being initiated on chemotherapy. The intervention was 10 weeks of weekly clinic-based application of two-component paste compression bandages. The primary outcome was change in the Lower Extremity Lymphedema Index (LELI) score from week 0 to week 14. The secondary outcomes were change in the Lymphedema Quality of Life measure (LYMQOL) and change in the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 score from week 0 to week 14. Blinded outcome assessments were conducted. RESULTS Of 30 participants randomly assigned, 25 eligible patients (chemotherapy [control], n = 13; com pression plus chemotherapy [intervention], n = 12) returned at week 14. Change in LELI, LYMQOL, and EORTC QLQ-C30 scores between week 14 and week 0 did not significantly differ by arm. The mean (standard deviation) change in LELI score was –25.9 (34.6) for the control arm compared with –13.3 (29.5) for the intervention arm, P = .340. The difference (95% CI) in the change in LELI score was –12.6 (–39.3 to 14.1). CONCLUSION Future studies evaluating a 14-week change in LELI for KS lymphedema should assume a standard deviation of approximately 30. Lessons learned from this pilot trial should inform the development of a larger, multicenter trial to evaluate the effectiveness of compression for KS lymphedema | en_US |
dc.description.sponsorship | Toby Maurer, Sonak D. Pastakia | en_US |
dc.language.iso | en | en_US |
dc.publisher | American society of clinical oncology | en_US |
dc.subject | Kaposi Sarcoma Leg Lymphedema | en_US |
dc.subject | HIV | en_US |
dc.subject | Chemotherapy | en_US |
dc.title | Compression therapy for HIV-associated Kaposi Sarcoma leg lymphedema: results of the Kenyan improvised compression for Kaposi Sarcoma randomized controlled trial | en_US |
dc.title.alternative | Rakhi Karwa | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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