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DC Field | Value | Language |
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dc.contributor.author | Fatuma, Some | - |
dc.contributor.author | Ayuo, Paul | - |
dc.contributor.author | Chumba, David Kiprop | - |
dc.contributor.author | Odipo, Osano | - |
dc.date.accessioned | 2022-01-25T05:44:42Z | - |
dc.date.available | 2022-01-25T05:44:42Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/5769 | - |
dc.description.abstract | Squamous cell esophageal cancer is common throughout East Africa, but its etiology is poorly understood. We investigated the contribution of alcohol consumption to esophageal cancer in Kenya, based on a hospital-based case-control study conducted from 08/2013 to 03/2018 in Eldoret, Western Kenya. Cases had an endoscopy-confirmed esophageal tumor whose histology did not rule out squamous cell carcinoma. Age and gender frequency-matched controls were recruited from hospital visitors/patients without digestive diseases. Logistic regression was used to calculate odds ratios (ORs) and their 95% confidence intervals (CI) adjusting for tobacco (type, intensity) and 6 other potential confounders. A total of 422 cases (65% male, mean at diagnosis 60 (SD 14) years) and 414 controls were included. ORs for ever-drinking were stronger in ever- tobacco users (9.0, 95% CI: 3.4, 23.8, with few tobacco users who were never drinkers) than in never-tobacco users (2.6, 95% CI: 1.6, 4.1). Risk increased linearly with number of drinks: OR for >6 compared to >0 to ≤2 drinks/day were 5.2 (2.4, 11.4) in ever-tobacco users and 2.1 (0.7, 4.4) in never-tobacco users. Although most ethanol came from low ethanol alcohols ( busaa or beer), for the same ethanol intake, if a greater proportion came from the moonshine chang’aa, it was associated with a specific additional risk. The population attributable fraction for >2 drinks per day was 48% overall and highest in male tobacco users. Alcohol consumption, particularly of busaa and chang’aa, contributes to half of the esophageal cancer burden in Western Kenya. | en_US |
dc.language.iso | en | en_US |
dc.publisher | HHS Public | en_US |
dc.subject | Esophageal cancer | en_US |
dc.subject | Alcohol | en_US |
dc.title | Traditional and commercial alcohols and esophageal cancer risk in Kenya HHS Public Access | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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File | Description | Size | Format | |
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nihms-993062.pdf | 477.21 kB | Adobe PDF | View/Open |
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