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Title: | Maternal tenofovir disoproxil fumarate use during pregnancy is not associated with adverse perinatal outcomes among HIV-infected East African women: a prospective study |
Authors: | Were, Edwin O. Pintye, Jillian Baeten, Jared M. Celum, Connie Mugo, Nelly Ngure, Kenneth Bukusi, Elizabeth A. |
Keywords: | Antiretroviral therapy Pregnancy loss Pre-exposure prophylaxis Preterm birth |
Issue Date: | 2017 |
Publisher: | Oxford University Press |
Abstract: | Background Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and pre-exposure prophylaxis regimens. We evaluated the relationship between adverse perinatal outcomes and prenatal TDF use. Methods Longitudinal data were analyzed from human immunodeficiency virus (HIV)-infected women who became pregnant during 2 HIV prevention studies conducted among HIV-serodiscordant couples in Kenya and Uganda. Pregnancies included were singleton, not terminated by an induced abortion, and had documented 3-drug ART use. Multivariate generalized estimating equation models were used to determine the association of prenatal TDF and perinatal outcomes. Results The most frequent ART regimens were TDF/3TC/EFV (39%) and AZT/3TC/NVP (34%); 49% of pregnancies had prenatal TDF exposure and 6% used a protease inhibitor. Neonatal death, preterm birth, and pregnancy loss occurred in 2%, 8%, and 12% of pregnancies, respectively. No differences were observed between pregnancies with and without exposure to TDF in the frequency of pregnancy loss (adjusted prevalence rate ratio [aPRR] 1.19, P = .8) or neonatal death (aPRR 0.68, P = .6). Preterm birth occurred less frequently among pregnancies exposed to TDF (aPRR, 0.34, P = .02). Conclusion Maternal TDF use did not adversely affect perinatal outcomes. |
URI: | https://doi.org/10.1093/infdis/jix542 http://ir.mu.ac.ke:8080/jspui/handle/123456789/4940 |
Appears in Collections: | School of Medicine |
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