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DC Field | Value | Language |
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dc.contributor.author | Kahle, Erin M. | - |
dc.contributor.author | Bolton, Michael | - |
dc.contributor.author | Hughes, James P. | - |
dc.contributor.author | Donnell, Deborah | - |
dc.contributor.author | Celum, Connie | - |
dc.contributor.author | Lingappa, Jairam R. | - |
dc.contributor.author | Ronald, Allan | - |
dc.contributor.author | Cohen, Craig R. | - |
dc.contributor.author | Bruyn, Guy de | - |
dc.contributor.author | Fong, Youyi | - |
dc.contributor.author | Katabira, Elly | - |
dc.contributor.author | McElrath, M. Juliana | - |
dc.contributor.author | Were, Edwin | - |
dc.date.accessioned | 2021-07-14T08:03:07Z | - |
dc.date.available | 2021-07-14T08:03:07Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://doi.org/10.1093/infdis/jiu621 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/4841 | - |
dc.description.abstract | Background. A heightened proinflammatory state has been hypothesized to enhance human immunodeficiency virus type 1 (HIV-1) transmission – both susceptibility of HIV-1-exposed persons and infectiousness of HIV-1-infected persons. Methods. Using prospective data from heterosexual African couples with HIV-1 serodiscordance, we conducted a nested case-control analysis to assess the relationship between cytokine concentrations and the risk of HIV-1 acquisition. Case couples (n = 120) were initially serodiscordant couples in which HIV-1 was transmitted to the seronegative partner during the study; control couples (n = 321) were serodiscordant couples in which HIV-1 was not transmitted to the seronegative partner. Differences in a panel of 30 cytokines were measured using plasma specimens from both HIV-1–susceptible and HIV-1–infected partners. Plasma was collected before seroconversion for cases. Results. For both HIV-1–infected and HIV-1–susceptible partners, cases and controls had significantly different mean responses in cytokine panels (P < .001, by the Hotelling T2 test), suggesting a broadly different pattern of immune activation for couples in which HIV-1 was transmitted, compared with couples without transmission. Individually, log10 mean concentrations of interleukin 10 (IL-10) and CXCL10 were significantly higher for both HIV-1–susceptible and HIV-1–infected case partners, compared with HIV-1–susceptible and HIV-1–infected control partners (P < .01 for all comparisons). In multivariate analysis, HIV-1 transmission was significantly associated with elevated CXCL10 concentrations in HIV-1–susceptible partners (P = .001) and with elevated IL-10 concentrations in HIV-1–infected partners (P = .02). Conclusions. Immune activation, as measured by levels of cytokine markers, particularly elevated levels of IL-10 and CXCL1, are associated with increased HIV-1 susceptibility and infectiousness. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Infectious diseases society of America | en_US |
dc.subject | HIV-1 transmission | en_US |
dc.subject | HIV-1 acquisition | en_US |
dc.subject | Serodiscordant couples | en_US |
dc.subject | Immune activation | en_US |
dc.title | Plasma cytokine levels and risk of HIV type 1 (HIV-1) transmission and acquisition: a Nested case-control study among HIV-1–serodiscordant couples | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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