Please use this identifier to cite or link to this item:
http://ir.mu.ac.ke:8080/jspui/handle/123456789/4825
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heffron, Renee | - |
dc.contributor.author | Donnell, Deborah | - |
dc.contributor.author | Rees, Helen | - |
dc.contributor.author | Celum, Connie | - |
dc.contributor.author | Mugo, Nelly | - |
dc.contributor.author | Were, Edwin | - |
dc.contributor.author | Bruyn, Guy de | - |
dc.contributor.author | Nakku-Joloba, Edith | - |
dc.contributor.author | Ngure, Kenneth | - |
dc.contributor.author | Kiarie, James | - |
dc.contributor.author | Coombs, Robert W. | - |
dc.contributor.author | Baeten, Jared M. | - |
dc.contributor.author | Partners in Prevention HSV/HIV Transmission Study Team | - |
dc.date.accessioned | 2021-07-12T07:50:07Z | - |
dc.date.available | 2021-07-12T07:50:07Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | https://doi.org/10.1016/S1473-3099(11)70247-X | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/4825 | - |
dc.description.abstract | Background Hormonal contraceptives are used widely but their effects on HIV-1 risk are unclear. Methods We followed 3790 heterosexual HIV-1 serodiscordant couples from seven African countries participating in two longitudinal HIV-1 incidence studies. Among hormonal contraceptive users (including injectable and oral contraceptive users) and nonusers, we compared rates of HIV-1 acquisition in women and HIV-1 transmission from women to men. Findings Among 1314 couples in which the HIV-1 seronegative partner was female, HIV-1 acquisition rates were 6.61 and 3.78 per 100 person-years among hormonal contraceptive users and nonusers (adjusted hazard ratio [AHR]=1.98, 95% confidence interval [CI] 1.06–3.68, p=0.03). Among 2476 couples in which the HIV-1 seronegative partner was male, HIV-1 transmission rates from women to men were 2.61 and 1.51 per 100 person-years in those whose partners currently used versus did not use hormonal contraception (AHR=1.97, 95% CI 1.12–3.45, p=0.02). In subgroup analysis, injectable contraceptive users had increased risk for acquiring and transmitting HIV-1 to their partner and HIV-1 seropositive women using injectable contraception had higher genital HIV-1 RNA concentrations, suggesting a mechanism for increased transmission risk. Oral contraceptives were used too infrequently to draw definitive conclusions about HIV-1 risk. Interpretation Women should be counseled about potentially increased risk of HIV-1 acquisition and transmission with hormonal contraception, particularly injectable methods, and about the importance of dual protection with condoms to decrease HIV-1 risk. Non-hormonal or lower-dose hormonal contraceptive methods should be considered for women with or at-risk for HIV-1. Funding National Institutes of Health (R03 HD068143, R01 AI083034, P30 AI027757, and T32 AI007140) and the Bill and Melinda Gates Foundation (26469 and 41185). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Hormonal contraception | en_US |
dc.subject | Serodiscordant couples | en_US |
dc.title | Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.