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DC Field | Value | Language |
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dc.contributor.author | Awino, Ooko Selline | - |
dc.contributor.author | Kiprono, Paul Chepkwony | - |
dc.contributor.author | Keronei, Kipkemboi Pius | - |
dc.contributor.author | Kaberia, Festus | - |
dc.contributor.author | Obala, Andrew Ambogo | - |
dc.date.accessioned | 2021-05-31T09:17:48Z | - |
dc.date.available | 2021-05-31T09:17:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | https://doi.org/10.1515/znc-2008-1-209 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/4541 | - |
dc.description.abstract | Chromatographic separation of an ethyl acetate extract from Embelia schimperi led to the isolation of a new compound identified as 2,5-dihydroxy-3-methyl-1,4-benzoquinone (1) on the basis of spectroscopic and physical data. The plant’s crude extract and pure compound 1 were assayed for in vitro antimicrobial activity against clinical strains of Salmonella spp., Proteus spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Cryptococcus neoformans, Shigella dysentriae and Staphylococcus aureus. Disc diffusion method was used and zones of inhibition, after respective incubation periods, were used to quantify antimicro- bial activity. Standard antibiotics namely: augmentin, cotrimoxazole, gentamycin, tetracycline and lyncomycin were used as controls. The crude extract was inactive while the pure compound 1 showed significant activities against Salmonella spp., Proteus spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, Es- cherichia coli, Cryptococcus neoformans, Shigella dysentriae and Staphylococcus aureus with zones of inhibition ranging from 10Ð20 mm. The most sensitive microorganism was P. aerugi- nosa while C. neoformans was insensitive to both the crude extract and compound 1 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Verlag der Zeitschrift für Naturforschung | en_US |
dc.subject | Embelia schimperi | en_US |
dc.subject | 2.5-Dihydroxy-3-methyl-1 | en_US |
dc.subject | 4-benzoquinone | en_US |
dc.title | Antimicrobial activity of 2, 5-dihydroxy-3-methyl-1, 4-benzoquinone from Embelia schimperi | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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