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Collection's Items (Sorted by Submit Date in Descending order): 61 to 78 of 78
Issue DateTitleAuthor(s)
2012Self-report of sexual behavior among adolescents is notoriously inconsistent, yet such measures are commonly used as outcomes for human immunodeficiency virus (HIV) prevention interven- tion trials. There has been a growing interest in the use of HIV and other sexually transmitted disease bio- markers as more valid measures of intervention impact in high HIV prevalence areas, particularly in sub- Saharan Africa. We examine the challenges, benefits, and feasibility of including HIV and herpes simplex virus type 2 (HSV-2) biomarker data, with details about different data collection and disclosure methods from two adolescent prevention trials in Kenya and Zimbabwe. In Kenya, whole blood samples were collected using venipuncture; adult guardians were present during biomarker procedures and test results were disclosed to participants and their guardians. In contrast, in Zimbabwe, samples were collected using finger pricks for dried blood spots (DBS); guardians were not present during biomarker procedures, and results were not disclosed to participants and/or their guardians. In both countries, prevalence in the study samples was low. Although the standard of care for testing for HIV and other sexually transmitted infec- tions includes disclosure in the presence of a guardian for adolescents under age 18, we conclude that more research about the risks and benefits of disclosure to adolescents in the context of a clinical trial is needed. Notably, current serological diagnosis for HSV-2 has a low positive predictive value when prevalence is low, resulting in an unacceptable proportion of false positives and serious concerns about disclosing test results to adolescents within a trial. We also conclude that the DBS approach is more convenient and efficient than venipuncture for field research, although both approaches are feasible.Mbai, Isabella I; Itindi, Janet
2014Use of HIV and HSV-2 biomarkers in Sub-Saharan adolescent prevention research: a comparison of two approachesLuseno, Winnie K.; Mbai, Isabella; Milimo, Benson
2011Keeping Adolescent Orphans in school to prevent Human Immunodeficiency Virus Infection: Evidence from a randomized controlled trial in KenyaMbai, Isabella I; Itindi, Janet; Milimo, Benson W
2017-05-27Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised …mabeya, Hillary
2011-05-27Stillbirths: the vision for 2020Mabeya, Hillary; L Goldenberg, Robert; M McClure, Elizabeth
2013-12A combined community-and facility-based approach to improve pregnancy outcomes in low-resource settings: a Global Network cluster randomized trialPasha, Omrana; M McClure, Elizabeth; L Wright, Linda; Esamai, Fabian
2018-06-01Determinants of breast cancer early detection for cues to expanded control and care: the lived experiences among women from Western KenyaKisiangani, Joyce; Baliddawa, Joyce; Marinda, Pamela; Mabeya, Hillary; Choge, Joseph K; Onyango Adino, Eric; Khayeka-Wandabwa, Christopher
2014-12First look: a cluster-randomized trial of ultrasound to improve pregnancy outcomes in low income country settingsEsamai, Fabian; Garces, Ana; Saleem, Sarah; O Nathan, Robert
2017-03-09A prospective study of maternal, fetal and neonatal outcomes in the setting of cesarean section in low- and middle-income countriesMargo S, Harrison; Omrana, Pasha; Saleem, Sarah; Esamai, Fabian
2016-08-15A pre-post study of a multi-country scale up of resuscitation training of facility birth attendants: does Helping Babies Breathe training save lives?M. Bellad, Roopa; Goco, Norman; Esamai, Fabian
2014An investigation into the perceptions and preferences of birth positions in a Kenyan referral hospitalMwanzia, Lydia
2016-11Development and validation of a rapid assessment tool for malaria preventionMangeni, Judith Nekesa; Menya, Diana; O’Meara, Wendy Prudhomme
2016-09The implementation of a Neonatal Nurse Training Program at the Riley Mother Baby hospital of KenyaSongok, Julia
2017-06Infertility in Africa: A great manifestation of gender discriminationChelagat, Dinah; Kerama, Emily Choge; Morogo, Wilson; Ayieko, Bilha M.
2017-04Factors influencing the occurrence of Diarrhea in children under five years in Chewoyet Sub-Location, Kapenguria Municipality, West Pokot County, Kenya.Ndwiga, Taratisio; Wanyonyi, Andrew
2016-07Assessment of uptake of free Maternity services among Women visiting Kisumu East District Hospital, Kisumu County, KenyaChepkemoi, Judy; Ndwiga, Taratisio
2017Factors associated with Schistosomiasis control measures in Mwaluphamba Location, Kwale County, KenyaAhmad, Juma; Arthur Ng’etich, K.S.; Naanyu, Violet; Mwangi, Ann; C. Kirinyet1, Ruth
2017-08Indication and outcomes of Caesaerian section at Moi Teaching & Referral Hospital, Eldoret, KenyaKagoni, Sarah Esendi; Mwangi, Anne; Chelagat, Dinah
Collection's Items (Sorted by Submit Date in Descending order): 61 to 78 of 78