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DC Field | Value | Language |
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dc.contributor.author | Simiyu, B.W | - |
dc.contributor.author | Mining, S. K. | - |
dc.contributor.author | Diero, LO | - |
dc.contributor.author | Ndede, I | - |
dc.contributor.author | Emonyi, W.I | - |
dc.contributor.author | Namasake, D. N. | - |
dc.contributor.author | Masengeli, N. L. | - |
dc.date.accessioned | 2021-01-14T09:49:21Z | - |
dc.date.available | 2021-01-14T09:49:21Z | - |
dc.date.issued | 2017-11-30 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/3851 | - |
dc.description.abstract | HIV-1 continues to be a major public health problem globally and particularly in Sub-Saharan Africa. The expression of CCR5 co-receptors and its influence on HIV-1 entry into host cells and tissues has been studied mostly in developed countries outside Africa. The impact of HAART on the expression of CCR5 co-receptor on host cells is little studied in Sub-Saharan Africa. This study focused on expression of CCR5 co-receptor on circulating CD4+ T cells in HIV-1 patients on HAART. A cross-sectional study design of 48 adult HIV-1 patients on HAART and an equal number of HAART naïve were recruited. Blood samples were assayed for CD4+ T cells and CCR5 co-receptor by FACS Calibur® while viral loads were quantified by COBAS® Amplicor version 2. The median expression (%) of CCR5 co-receptors on CD4+T were1.32 and 0.80 in patients on HAART and HAART naïve respectively, p=0.003. The median in the viral loads (copies/ml) were 111.5 and 39301 in patients on HAART and the HAART naïve respectively, p=0.001.This study concluded that HAART up-regulates CCR5 co-receptor expression in HIV-1 infected participants compared to HIV-1 infected but HAART naïve counterparts. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Journal of Development Research | en_US |
dc.subject | HIV-1 | en_US |
dc.subject | CCR5 Co-receptors | en_US |
dc.subject | HAART | en_US |
dc.subject | CD4+ T Cells | en_US |
dc.title | Ccr5 co-receptor expression on circulating cd4+lymphocytes in hiv-1 patients on haart at moi teaching and referral hospital, eldoret-Kenya | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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Copyright ©2017, Simiyu et al..pdf | 246.32 kB | Adobe PDF | View/Open |
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