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Title: | Detection of types of HPV among HIV‐infected and HIV‐uninfected Kenyan women undergoing cryotherapy or loop electrosurgical excision procedure |
Authors: | Orang’o, Elkanah O. Omodi, Victor Itsura, Peter M. Tonui, Philip K. Muthoka, Kapten Kiptoo, Stephen |
Keywords: | Cryotherapy procedure Invasive cervical cancer |
Issue Date: | 2020 |
Publisher: | International Journal of Gynecology & Obstetrics |
Abstract: | Objective To assess the baseline types of HPV infection among HIV‐positive and HIV‐negative women in western Kenya undergoing cryotherapy or loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia. Methods A prospective observational study was conducted of baseline HPV characteristics of women undergoing visual inspection with acetic acid (VIA) and cryotherapy or LEEP. After a positive VIA in HIV‐positive and HIV‐negative women, data on demographics, CD4 count, and use of antiretroviral therapy and a cervical swab were collected. HPV typing was performed using the Roche Linear Array. Results Of 175 participants, 86 (49.1%) were HIV‐positive and had a higher prevalence of low‐risk HPV types (odds ratio [OR] 5.28, P=0.005) compared with HIV‐negative women. The most common high‐risk (HR)‐HPV types in HIV‐positive women were HPV 16 (13.9%) and HPV 18 (11.1%). HIV‐positive women requiring LEEP were more likely to have HR‐HPV types (OR 6.67, P=0.012) and to be infected with multiple HR‐HPV types (OR 7.79, P=0.024) compared to those undergoing cryotherapy. Conclusion HIV‐positive women requiring LEEP versus cryotherapy had a higher prevalence of any HR‐HPV type and multiple HR‐HPV types. There were no such differences in HPV types identified among HIV‐negative women. |
URI: | https://doi.org/10.1002/ijgo.13330 http://ir.mu.ac.ke:8080/jspui/handle/123456789/3627 |
Appears in Collections: | School of Medicine |
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