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Title: | Low sensitivity of the careHPVTM Assay for detection of Oncogenic Human Papillomavirus in cervical samples from HIV-infected and HIV-uninfected Kenyan women |
Authors: | Chelimo K |
Keywords: | HIV-infected HIV-uninfected |
Issue Date: | 2020 |
Publisher: | International Journal of Clinical Virology |
Abstract: | ackground: Human papillomavirus (HPV) infection causes cervical cancer (CC), a common malignancy among Kenyan women. New CC screening methods rely on oncogenic HPV (“high- risk”, or HR-HPV) detection, but most have not been evaluated in swabs from Kenyan women. Methods: HPV typing was performed on 155 cervical swabs from Kenyan women using the Roche Linear Array ® (LA) and careHPVTM (careHPV) assays. Detection of 14 oncogenic HPV types in careHPV assay was compared to LA results. Results: Compared to LA, sensitivity and specifi city of careHPV assay was 53.0% and 80.9%, respectively. The sensitivity and specifi city of careHPV in swabs from women with cervical dysplasia was 74.1% and 65.2%, respectively. The sensitivity and specifi city of careHPV in swabs from HIV-infected women was 55.9% and of 96.4%, respectively. Overall agreements of careHPV assay with LA was substantial. Conclusion: The results for careHPV assay are promising for oncogenic HPV detection in Kenyan women. The low sensitivity of careHPV for detection of HR-HPV could limit it’s benefi t as a screening tool. Thus, a full clinical validation study is highly desirable before the careHPV assay can be accepted for cervical cancer screening. |
URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/3559 |
Appears in Collections: | School of Medicine |
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Low sensitivity of the careHPVTM Assay | 187.21 kB | Adobe PDF | ![]() View/Open |
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