Please use this identifier to cite or link to this item:
http://ir.mu.ac.ke:8080/jspui/handle/123456789/3543
Title: | HIV coinfection is associated with low-fitness rpoB variants in Rifampicin-resistant mycobacterium tuberculosis |
Authors: | Loiseau, Chloé Brites, Daniela Reinhard, Miriam Zürcher, Kathrin Borrell, Sonia Ballif, Marie Fenner, Lukas Cox, Helen Rutaihwa, Liliana K. Wilkinson, Robert J. Yotebieng, Marcel Carter, E. Jane Alash’le, Abimiku Olivier, Marcy |
Keywords: | HIV-TB coinfection Mycobacterium tuberculosis Drug resistance Fitness cost rifampicin |
Issue Date: | 2020 |
Publisher: | American Society |
Abstract: | We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. |
URI: | https://aac.asm.org/content/64/10/e00782-20 http://ir.mu.ac.ke:8080/jspui/handle/123456789/3543 |
Appears in Collections: | School of Medicine |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.