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DC Field | Value | Language |
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dc.contributor.author | Loiseau, Chloé | - |
dc.contributor.author | Brites, Daniela | - |
dc.contributor.author | Reinhard, Miriam | - |
dc.contributor.author | Zürcher, Kathrin | - |
dc.contributor.author | Borrell, Sonia | - |
dc.contributor.author | Ballif, Marie | - |
dc.contributor.author | Fenner, Lukas | - |
dc.contributor.author | Cox, Helen | - |
dc.contributor.author | Rutaihwa, Liliana K. | - |
dc.contributor.author | Wilkinson, Robert J. | - |
dc.contributor.author | Yotebieng, Marcel | - |
dc.contributor.author | Carter, E. Jane | - |
dc.contributor.author | Alash’le, Abimiku | - |
dc.contributor.author | Olivier, Marcy | - |
dc.date.accessioned | 2020-10-14T07:07:38Z | - |
dc.date.available | 2020-10-14T07:07:38Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://aac.asm.org/content/64/10/e00782-20 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/3543 | - |
dc.description.abstract | We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Society | en_US |
dc.subject | HIV-TB coinfection | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | Drug resistance | en_US |
dc.subject | Fitness cost | en_US |
dc.subject | rifampicin | en_US |
dc.title | HIV coinfection is associated with low-fitness rpoB variants in Rifampicin-resistant mycobacterium tuberculosis | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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