HIV coinfection is associated with low-fitness rpoB variants in Rifampicin-resistant mycobacterium tuberculosis

Please use this identifier to cite or link to this item: http://ir.mu.ac.ke:8080/jspui/handle/123456789/3543

Title:	HIV coinfection is associated with low-fitness rpoB variants in Rifampicin-resistant mycobacterium tuberculosis
Authors:	Loiseau, Chloé Brites, Daniela Reinhard, Miriam Zürcher, Kathrin Borrell, Sonia Ballif, Marie Fenner, Lukas Cox, Helen Rutaihwa, Liliana K. Wilkinson, Robert J. Yotebieng, Marcel Carter, E. Jane Alash’le, Abimiku Olivier, Marcy
Keywords:	HIV-TB coinfection Mycobacterium tuberculosis Drug resistance Fitness cost rifampicin
Issue Date:	2020
Publisher:	American Society
Abstract:	We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.
URI:	https://aac.asm.org/content/64/10/e00782-20 http://ir.mu.ac.ke:8080/jspui/handle/123456789/3543
Appears in Collections:	School of Medicine

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