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DC Field | Value | Language |
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dc.contributor.author | Orang’o, Omenge | - |
dc.contributor.author | Tonui, Philip | - |
dc.contributor.author | Tong, Yan | - |
dc.contributor.author | Maina, Titus | - |
dc.contributor.author | Kiptoo, Stephen | - |
dc.contributor.author | Muthoka, Katpen | - |
dc.date.accessioned | 2020-08-14T08:10:35Z | - |
dc.date.available | 2020-08-14T08:10:35Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://doi.org/10.1093/ofid/ofz354 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/3427 | - |
dc.description.abstract | Background Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor. Methods Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus-uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration. Results Valid HPV testing results were available for 86 women (mean age 34.0 years); 49 women (57.0%) had AFB1-lys detected and 37 (43.0%) had none. The AFB1-lys detection was not associated with age, being married, having more than secondary school education, home ownership, living at a walking distance to healthcare ≥60 minutes, number of lifetime sex partners, or age of first sex. The AFB1-lys detection and plasma concentrations were associated with detection of oncogenic HPV types. Conclusions The AFB1-lys positivity and higher plasma AFB1-lys concentrations were associated with higher risk of oncogenic HPV detection in cervical samples from Kenya women. Further studies are needed to determine whether aflatoxin interacts with HPV in a synergistic manner to increase the risk of cervical cancer. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.subject | Oncogenic human papillomavirus | en_US |
dc.subject | Plasma aflatoxin | en_US |
dc.subject | Cervical cancer | en_US |
dc.title | Detection and concentration of plasma aflatoxin is associated with detection of oncogenic human papillomavirus in Kenyan women | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
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