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Title: | Reduced transplacental transfer of antimalarial antibodies in kenyan HIV-exposed uninfected infants |
Authors: | Ray, Jessica E Dobbs, Katherine R Ogolla, Sidney O Daud, Ibrahim I |
Keywords: | Antimalarial antibodies Transplacental antibody transfer |
Issue Date: | 2019 |
Publisher: | Oxford academic |
Abstract: | Background Altered neonatal immune responses may contribute to the increased morbidity observed in HIV-exposed but uninfected (HEU) infants compared with HIV-unexposed uninfected (HUU) infants. We sought to examine the effects of prenatal HIV and malaria exposure on maternal and neonatal plasma cytokine profiles and transplacental antibody transfer. Methods Forty-nine HIV+ and 50 HIV- women and their HIV-uninfected neonate pairs from Kenya were assessed. All HIV+ mothers received combination antiretroviral therapy. Maternal plasma and cord blood plasma samples at delivery were tested for 12 cytokines, total IgG, and IgG specific to 4 vaccine antigens and 14 Plasmodium falciparum antigens. Results HIV+ mothers had lower levels of all 12 plasma cytokines at delivery compared with HIV- mothers, but there were no differences between HEU and HUU neonates. There were no differences in the cord-to-maternal ratios (CMRs) of vaccine-specific IgG between HIV+/HEU and HIV-/HUU maternal–neonate pairs. HIV+/HEU maternal–neonate pairs had significantly lower CMRs for 3 antimalarial IgGs—merozoite surface protein 9, circumsporozoite protein, and erythrocyte binding antigen 181—which remained statistically significant after adjustment for malaria in pregnancy. Conclusions In a cohort of optimally treated HIV-infected pregnant women, maternal HIV infection was associated with reduced transplacental transfer of antimalarial antibodies. |
URI: | https://doi.org/10.1093/ofid/ofz237 http://ir.mu.ac.ke:8080/jspui/handle/123456789/3408 |
Appears in Collections: | School of Medicine |
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