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Title: | Sickle cell disease and HIV: a case highlighting management challenges for children in a resource - limited setting. |
Authors: | Odera, Esther Brenda Kwobah, Charles Stone, Geren Some, Faraj |
Keywords: | Sickle cell disease Antiretroviral therapy Comorbidity |
Issue Date: | 2013 |
Publisher: | Sage |
Abstract: | Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients. |
URI: | https://doi.org/10.1177/2325957413508320 http://ir.mu.ac.ke:8080/jspui/handle/123456789/3202 |
Appears in Collections: | School of Medicine |
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