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http://ir.mu.ac.ke:8080/jspui/handle/123456789/3057
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DC Field | Value | Language |
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dc.contributor.author | Lingappa, Jairam R. | - |
dc.contributor.author | Lambdin, Barrot. | - |
dc.contributor.author | Ann Bukusi, Elizabeth. | - |
dc.contributor.author | Ngure, Kenneth. | - |
dc.contributor.author | Kavuma, Linda. | - |
dc.contributor.author | Inambao, Mubiana. | - |
dc.contributor.author | Kanweka, William. | - |
dc.contributor.author | Allen., Susan. | - |
dc.contributor.author | N. Kiarie, James. | - |
dc.contributor.author | Makhema, Joseph. | - |
dc.contributor.author | Were, Edwin. | - |
dc.contributor.author | Manongi, Rachel. | - |
dc.contributor.author | Coetzee, David. | - |
dc.contributor.author | de Bruyn, Guy. | - |
dc.contributor.author | Delany-Moretlwe, Sinead. | - |
dc.contributor.author | Magaret, Amalia. | - |
dc.contributor.author | Mugo, Nelly. | - |
dc.contributor.author | Mujugira, Andrew. | - |
dc.contributor.author | Ndase, Patrick. | - |
dc.contributor.author | Celum, Connie. | - |
dc.date.accessioned | 2020-06-04T09:17:42Z | - |
dc.date.available | 2020-06-04T09:17:42Z | - |
dc.date.issued | 2008-01-01 | - |
dc.identifier.citation | Citation: Lingappa JR, Lambdin B, Bukusi EA, Ngure K, Kavuma L, et al (2008) Regional Differences in Prevalence of HIV-1 Discordance in Africa and Enrollment of HIV-1 Discordant Couples into an HIV-1 Prevention Trial. | en_US |
dc.identifier.uri | http://ir.mu.ac.ke:8080/jspui/handle/123456789/3057 | - |
dc.description.abstract | Background. Most HIV-1 transmission in Africa occurs among HIV-1-discordant couples (one partner HIV-1 infected and one uninfected) who are unaware of their discordant HIV-1 serostatus. Given the high HIV-1 incidence among HIV-1 discordant couples and to assess efficacy of interventions for reducing HIV-1 transmission, HIV-1 discordant couples represent a critical target population for HIV-1 prevention interventions and prevention trials. Substantial regional differences exist in HIV-1 prevalence in Africa, but regional differences in HIV-1 discordance among African couples, has not previously been reported. Methodology/ Principal Findings. The Partners in Prevention HSV-2/HIV-1 Transmission Trial (‘‘Partners HSV-2 Study’’), the first large HIV-1 prevention trial in Africa involving HIV-1 discordant couples, completed enrollment in May 2007. Partners HSV-2 Study recruitment data from 12 sites from East and Southern Africa were used to assess HIV-1 discordance among couples accessing couples HIV-1 counseling and testing, and to correlate with enrollment of HIV-1 discordant couples. HIV-1 discordance at Partners HSV-2 Study sites ranged from 8–31% of couples tested from the community. Across all study sites and, among all couples with one HIV-1 infected partner, almost half (49%) of couples were HIV-1 discordant. Site-specific monthly enrollment of HIV-1 discordant couples into the clinical trial was not directly associated with prevalence of HIV-1 discordance, but was modestly correlated with national HIV-1 counseling and testing rates and access to palliative care/basic health care (r= 0.74, p = 0.09). Conclusions/Significance. HIV-1 discordant couples are a critical target for HIV-1 prevention in Africa. In addition to community prevalence of HIV-1 discordance, national infrastructure for HIV-1 testing and healthcare delivery and effective community outreach strategies impact recruitment of HIV-1 discordant couples into HIV-1 prevention trials. | en_US |
dc.language.iso | en | en_US |
dc.publisher | medical publication | en_US |
dc.subject | HIV-1 transmission | en_US |
dc.subject | HIV-1-discordant couples | en_US |
dc.subject | HIV-1 prevention interventions and prevention trials | en_US |
dc.title | Regional Differences in Prevalence of HIV-1 Discordance in Africa and Enrollment of HIV-1 Discordant Couples into an HIV-1 Prevention Trial | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine |
Files in This Item:
File | Description | Size | Format | |
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Jairam R. Lingappa.....et al.pdf | 90.69 kB | Adobe PDF | View/Open |
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