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http://ir.mu.ac.ke:8080/jspui/handle/123456789/2988
Title: | Outcomes of HIV-Infected Orphaned and Non-Orphaned Children on Antiretroviral Therapy in Western Kenya |
Authors: | Nyandiko, M. Winstone Ayaya, Samuel Nabakwe, Esther Tenge, Constance Sidle, E. John Yiannoutsos, T. Constantin Musick, Beverly Wools-Kaloustian, Kara Tierney, M. William |
Keywords: | HIV antiretroviral therapy Western Kenya children orphan |
Issue Date: | 1-Dec-2006 |
Publisher: | Ampath |
Abstract: | Objectives: Determine outcome differences between orphaned and non-orphaned children receiving antiretroviral therapy (ART). Design: Retrospective review of prospectively recorded electronic data. orphan Setting: Nine HIV clinics in western Kenya. Population: 279 children on ART enrolled between August 2002 and February 2005. Main Measures: Orphan status, CD4%, sex- and age-adjusted height (HAZ) and weight (WAZ) z scores, ART adherence, mortality. Results: Median follow-up was 34 months. Cohort included 51% males and 54% orphans. At ART initiation (baseline), 71% of children had CDC clinical stage B or C disease. Median CD4% was 9% and increased dramatically the first 30 weeks of therapy, then leveled off. Parents and guardians reported perfect adherence at every visit for 75% of children. Adherence and orphan status were not significantly associated with CD4% response. Adjusted for baseline age, follow-up was significantly shorter among orphaned children (median 33 vs. 41 weeks, P = 0.096). One-year mortality was 7.1% for orphaned and 6.6% for non-orphaned children (P = 0.836). HAZ and WAZ were significantly below norm in both groups. With ART, HAZ remained stable, while WAZ tended to increase toward the norm, especially among non-orphans. Orphans showed identical weight gains as non-orphans the first 70 weeks after start of ART but experienced reductions afterwards. |
URI: | http://ir.mu.ac.ke:8080/jspui/handle/123456789/2988 |
Appears in Collections: | School of Medicine |
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File | Description | Size | Format | |
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Samuel Ayaya etal 2006.pdf | 273.91 kB | Adobe PDF | View/Open |
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