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DC Field | Value | Language |
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dc.contributor.author | Ochieng, C.O | - |
dc.contributor.author | Ishola, I.O, | - |
dc.contributor.author | Opiyo, S.A | - |
dc.contributor.author | Manguro, L.A.O. | - |
dc.date.accessioned | 2018-09-20T07:19:29Z | - |
dc.date.available | 2018-09-20T07:19:29Z | - |
dc.date.issued | 2014-09 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/xmlui/handle/123456789/1760 | - |
dc.description.abstract | Vitex doniana (Verbenaceae) is small to medium sized tree up to 25 m tall tropical tree with no phytochemical report in spite of the available ethnopharmacological significance among different African communities [1-2], including management of stomach, rheumatic pains and inflammatory disorders [3].Antidepressant effects, potentiation of sodium thiopental sleeping time, muscle relaxant [4], anti-inflammatory and analgesic activities [1] of the leaves extract of V. doniana have been investigated and anti-hypertensive effect of the stem bark has been reported on normative and hypertensive rats [5]. The potent anti-inflammatory activity of the extracts of V. doniana with no phytopharmaceuticals associated with the activity prompted phytochemical analysis of the V. doniana stem bark for anti-inflammatory compounds. In this note, isolation of three new ecdysteroids [21-hydroxyshidasterone (1), 11-hydroxy-20-deoxyshidasterone (2), 2,3-acetonide-24-hydroxyecdysone (3)] and four known ecdysteroids [shidasterone (4), ajugasterone C (5) 24-hydroxyecdysone (6)11α-Hydroxyecdysone (7)] with comparable anti-inflammatory activities as diclofenac is reported | en_US |
dc.language.iso | en | en_US |
dc.publisher | Moi University | en_US |
dc.subject | Vitex doniana | en_US |
dc.subject | Verbenaceae | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.subject | 21-hydroxyshidasterone | en_US |
dc.subject | 11-hydroxy-20-deoxyshidasterone | en_US |
dc.subject | 2,3-acetonide-24-hydroxyecdysone | en_US |
dc.title | Phytoecdysteroids from the stem bark of Vitex doniana with anti-inflammatory activities | en_US |
Appears in Collections: | College of Health Sciences |
Files in This Item:
File | Description | Size | Format | |
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Ochieng C.O et al.pdf | 487.23 kB | Adobe PDF | View/Open |
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